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6.5.1.3: RNA ligase (ATP)

This is an abbreviated version!
For detailed information about RNA ligase (ATP), go to the full flat file.

Word Map on EC 6.5.1.3

Reaction

(ribonucleotide)n-3'-hydroxyl
+
5'-(5'-diphosphoadenosine)-(ribonucleotide)m
=
(ribonucleotide)n+m
 +
AMP

Synonyms

ATP-dependent RNA ligase, b1-10t, bacteriophage RNA ligase, band IV protein, class I ligase, class I RNA ligase ribozyme, DraRnI, DraRnl, DREL, gp24.1, P52, phage Rnl2, Polynucleotide synthetase, Polyribonucleotide ligase, Polyribonucleotide synthase (ATP), REL1, Ribonucleic ligase, ribonucleprotein editing complex, RM378 RNA ligase, RNA editing ligase 1, RNA ligase, RNA ligase (ATP), RNA ligase 1, RNA ligase 2, RNA ligase ribozyme, RNA-editing ligase 1, RNL, Rnl1, Rnl2, Rnl5, RnlA, RtcA, rtcB, Synthetase, polyribonucleotide, T4 RNA ligase, T4 RNA ligase 1, T4 RNA ligase 2, T4Rnl2, TbMP52, TbREL1, thermostable RNA ligase 1, Trl1

ECTree

     6 Ligases
         6.5 Forming phosphoric-ester bonds
             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
                6.5.1.3 RNA ligase (ATP)

Inhibitors

Inhibitors on EC 6.5.1.3 - RNA ligase (ATP)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,N6-Ethenoadenosine 5'-triphosphate
Tequatrovirus T4
-
-
1-amino-4-(3-(aminosulfonyl)anilino)-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
68.5% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations
2',5'-ADP
Tequatrovirus T4
-
poly(A) cyclization
2-naphthoic acid
-
2-nitronaphthalene
-
3-((4-(ethylamino)phenyl)diazenyl)-4,5-dihydroxy-2,7-naphthalenedisulfonic acid
4.1% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations
3-((5-chloro-2-hydroxyphenyl)diazenyl)-4,5-dihydroxy-2,7-naphthalenedisulfonic acid
8.6% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations
4,5-dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid
43.1% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations
4,5-dihydroxynaphthalene-2,7-disulfonate
-
4-hydroxy-3-[(E)-(5-hydroxy-7-sulfonaphthalen-2-yl)diazenyl]-7-[(1-phenylethenyl)amino]naphthalene-2-sulfonic acid
-
6-Chloropurine riboside 5'-triphosphate
Tequatrovirus T4
-
-
6-hydroxy-5-[(E)-[3-[(E)-(2-hydroxynaphthalen-1-yl)diazenyl]-5-sulfophenyl]diazenyl]naphthalene-2-sulfonic acid
-
6-mercaptopurine riboside 5'-triphosphate
Tequatrovirus T4
-
-
7,7'-iminobis(4-hydroxynaphthalene-2-sulfonic acid)
-
7-amino-4-hydroxy-3-[(E)-(5-hydroxy-7-sulfonaphthalen-2-yl)diazenyl]naphthalene-2-sulfonic acid
-
8-bromoadenosine 5'-triphosphate
Tequatrovirus T4
-
-
8-Sulfoadenosine 5'-triphosphate
Tequatrovirus T4
-
-
adenosine 5'-tetraphosphate
Tequatrovirus T4
-
-
adenosine-N1-oxide 5'-triphosphate
Tequatrovirus T4
-
-
ADP
Tequatrovirus T4
-
-
AMP
Tequatrovirus T4
-
-
ATP
-
above 2.5 mM, complete inhibition at 10 mM. The inhibition can be partially rescued by adding more Mg2+ to the reaction
beta,gamma-imine-ATP
Tequatrovirus T4
-
-
beta,gamma-methylene-ATP
Tequatrovirus T4
-
-
Co(NH3)63+
-
-
gamma-Thio-ATP
Tequatrovirus T4
-
-
ITP
Tequatrovirus T4
-
-
Mg2+
-
inhibits above 10 mM, required at lower concentrations
naphthalene-2-sulfonic acid
-
P1,P3-di(adenosine-5')triphosphate
Tequatrovirus T4
-
-
P1,P4-di(adenosine-5')tetraphosphate
Tequatrovirus T4
-
-
tripolyphosphate
Tequatrovirus T4
-
-
additional information
-
inhibitors in infectious microorganisms
-