6.5.1.3: RNA ligase (ATP)

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For detailed information about RNA ligase (ATP), go to the full flat file.

Reaction

Synonyms

ATP-dependent RNA ligase, b1-10t, bacteriophage RNA ligase, band IV protein, class I ligase, class I RNA ligase ribozyme, DraRnI, DraRnl, DREL, gp24.1, P52, phage Rnl2, Polynucleotide synthetase, Polyribonucleotide ligase, Polyribonucleotide synthase (ATP), REL1, Ribonucleic ligase, ribonucleprotein editing complex, RM378 RNA ligase, RNA editing ligase 1, RNA ligase, RNA ligase (ATP), RNA ligase 1, RNA ligase 2, RNA ligase ribozyme, RNA-editing ligase 1, RNL, Rnl1, Rnl2, Rnl5, RnlA, RtcA, rtcB, Synthetase, polyribonucleotide, T4 RNA ligase, T4 RNA ligase 1, T4 RNA ligase 2, T4Rnl2, TbMP52, TbREL1, thermostable RNA ligase 1, Trl1

ECTree

     6 Ligases

         6.5 Forming phosphoric-ester bonds

             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

                6.5.1.3 RNA ligase (ATP)

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2	Activating Compound
2439	AA Sequence
7	Application
1	CAS Registry Number
24	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
44	Disease/ Diagnostics
2	General Information
3	General Stability
4	IC50 Value
43	Inhibitors
7	kcat/KM [mM/s]
18	KM Value [mM]
10	Localization
25	Metals/Ions
14	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
79	Organism
24	PDB ID
15	pH Optimum
6	pH Range
181	Protein Variants
31	Purification (Commentary)
5	Reaction
2	Reaction Type
79	Reference
10	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
136	Substrates and Products (Substrate)
9	Subunits
85	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
22	Turnover Number [1/s]

pH Range

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pH Range on EC 6.5.1.3 - RNA ligase (ATP)

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 9.5

Vibrio phage KVP40

-

activity is virtually nil at pH below 5.0 or above 9.5

654015

5.5 - 8

Tequatrovirus T4

-

adenylyltransferase activity

653679

5.5 - 8.5

Naegleria gruberi

-

nick sealing activity is optimal at pH 5.5 to 6.5 and declined sharply at pH 8.5 or above

749277

5.7 - 7

synthetic construct

-

-

650172

6.5 - 8

Tequatrovirus T4

-

around 70% of the maximum at pH 8.0

651051

7 - 8.5

Phage TS2126

-

pH 7.0: about 40% of maximal activity, pH 8.5: about 30% of maximal activity

662976