6.5.1.3: RNA ligase (ATP)

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For detailed information about RNA ligase (ATP), go to the full flat file.

Reaction

Synonyms

ATP-dependent RNA ligase, b1-10t, bacteriophage RNA ligase, band IV protein, class I ligase, class I RNA ligase ribozyme, DraRnI, DraRnl, DREL, gp24.1, P52, phage Rnl2, Polynucleotide synthetase, Polyribonucleotide ligase, Polyribonucleotide synthase (ATP), REL1, Ribonucleic ligase, ribonucleprotein editing complex, RM378 RNA ligase, RNA editing ligase 1, RNA ligase, RNA ligase (ATP), RNA ligase 1, RNA ligase 2, RNA ligase ribozyme, RNA-editing ligase 1, RNL, Rnl1, Rnl2, Rnl5, RnlA, RtcA, rtcB, Synthetase, polyribonucleotide, T4 RNA ligase, T4 RNA ligase 1, T4 RNA ligase 2, T4Rnl2, TbMP52, TbREL1, thermostable RNA ligase 1, Trl1

ECTree

     6 Ligases

         6.5 Forming phosphoric-ester bonds

             6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

                6.5.1.3 RNA ligase (ATP)

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Results	in table
2	Activating Compound
2439	AA Sequence
7	Application
1	CAS Registry Number
24	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
44	Disease/ Diagnostics
2	General Information
3	General Stability
4	IC50 Value
43	Inhibitors
7	kcat/KM [mM/s]
18	KM Value [mM]
10	Localization
25	Metals/Ions
14	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
79	Organism
24	PDB ID
15	pH Optimum
6	pH Range
181	Protein Variants
31	Purification (Commentary)
5	Reaction
2	Reaction Type
79	Reference
10	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
136	Substrates and Products (Substrate)
9	Subunits
85	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
22	Turnover Number [1/s]

Application

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Application on EC 6.5.1.3 - RNA ligase (ATP)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Trypanosoma brucei

-

regulated repression of the enzyme blocks editing, this repression is lethal in bloodforms of the parasite, indicating that editing is essential in the mammalian stage of the life cycle, the editing complex, which is present in all kinetoplastid parasites, may thus be a chemotherapeutic target

653889

molecular biology

2 entries

synthesis

4 entries

molecular biology

Phage TS2126

-

RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE)

662976

molecular biology

Phage TS2126

-

the properties of TS2126 RNA ligase 1 makes it very attractive for processes like adaptor ligation, and single-stranded solid phase gene synthesis

662976

synthesis

Tequatrovirus T4

-

synthesis of oligoribonucleotides with defined sequence

1989

synthesis

Tequatrovirus T4

-

RNA ligase-mediated method for the efficient creation of large, synthetic RNAs

677096

synthesis

Tequatrovirus T4

-

selective isotope labeling of RNA by introducing a labeled RNA segment via a two-step protocol, which uses T4 DNA ligase and T4 RNA ligase 1, and a one-pot protocol, which uses T4 RNA ligase 1 alone. Protection of termini is not required, provided segmentation sites can be chosen such that the segments fold into the target structure or target-like structures and thus are not trapped into stable alternate structures. Labeling protocols are generally applicable to large RNA molecules and can be extended to more than three segments

694461

synthesis

Methanothermobacter thermautotrophicus

-

efficient synthesis of 5' pre-adenylated DNA

728392