6.5.1.3: RNA ligase (ATP)

This is an abbreviated version!
For detailed information about RNA ligase (ATP), go to the full flat file.

Word Map on EC 6.5.1.3

6.5.1.3

trna

polynucleotide

ligases

phosphodiester

termini

rnase

brucei

single-stranded

oligoribonucleotides

3'-terminal

adenylylation

3'-phosphate

5\'-hydroxyl

kinetoplastids

anticodons

aminoacylation

nucleotidyl

3',5'-bisphosphate

rlm-race

nucleotidyltransferase

trnaphe

3',5'-phosphodiester

uridylate

5'-phosphorylated

viroid

editosome

3'-phosphodiesterase

tarentolae

t4-induced

half-molecules

splint

hammerhead

trnafmet

rolling-circle

deoxyribozymes

tutase

template-directed

t4-infected

5\'-half

medicine

synthesis

molecular biology

Reaction

5'-(5'-diphosphoadenosine)-(ribonucleotide)m

Synonyms

ATP-dependent RNA ligase, b1-10t, bacteriophage RNA ligase, band IV protein, class I ligase, class I RNA ligase ribozyme, DraRnI, DraRnl, DREL, gp24.1, P52, phage Rnl2, Polynucleotide synthetase, Polyribonucleotide ligase, Polyribonucleotide synthase (ATP), REL1, Ribonucleic ligase, ribonucleprotein editing complex, RM378 RNA ligase, RNA editing ligase 1, RNA ligase, RNA ligase (ATP), RNA ligase 1, RNA ligase 2, RNA ligase ribozyme, RNA-editing ligase 1, RNL, Rnl1, Rnl2, Rnl5, RnlA, RtcA, rtcB, Synthetase, polyribonucleotide, T4 RNA ligase, T4 RNA ligase 1, T4 RNA ligase 2, T4Rnl2, TbMP52, TbREL1, thermostable RNA ligase 1, Trl1

ECTree

6 Ligases

6.5 Forming phosphoric-ester bonds

6.5.1 Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

6.5.1.3 RNA ligase (ATP)

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Results	in table
2	Activating Compound
2439	AA Sequence
7	Application
1	CAS Registry Number
24	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
44	Disease/ Diagnostics
2	General Information
3	General Stability
4	IC50 Value
43	Inhibitors
7	kcat/KM [mM/s]
18	KM Value [mM]
10	Localization
25	Metals/Ions
14	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
79	Organism
24	PDB ID
15	pH Optimum
6	pH Range
181	Protein Variants
31	Purification (Commentary)
5	Reaction
2	Reaction Type
79	Reference
10	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
136	Substrates and Products (Substrate)
9	Subunits
85	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
22	Turnover Number [1/s]

Reaction

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Reaction on EC 6.5.1.3 - RNA ligase (ATP)

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(ribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(ribonucleotide)m = (ribonucleotide)n+m + AMP

(1c)

ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide

2 entries

ATP + [RNA ligase]-L-lysine = [RNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate

(1a)

[RNA ligase]-N6-(5'-adenylyl)-L-lysine + 5'-phospho-(ribonucleotide)m = 5'-(5'-diphosphoadenosine)-(ribonucleotide)m + [RNA ligase]-L-lysine

(1b)