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6.3.4.2: CTP synthase (glutamine hydrolysing)

This is an abbreviated version!
For detailed information about CTP synthase (glutamine hydrolysing), go to the full flat file.

Word Map on EC 6.3.4.2

Reaction

ATP
+
UTP
 +
L-glutamine
=
ADP
 +
phosphate
 +
CTP
 +
L-glutamate

Synonyms

CTP synthase, CTP synthase 1, CTP synthetase, CTP synthetase 1, CTPS, CTPS1, CTPS2, CTPsyn, CTS, cytidine 5'-triphosphate synthase, cytidine 5'-triphosphate synthetase, cytidine triphosphate synthetase, cytidine triphosphate synthetase 1, EcCTPS, pfCTP synthetase, PyrG, synthetase, cytidine triphosphate, URA7, uridine triphosphate aminase, UTP-ammonia ligase, UTP:ammonia ligase (ADP-forming)

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.2 CTP synthase (glutamine hydrolysing)

IC50 Value

IC50 Value on EC 6.3.4.2 - CTP synthase (glutamine hydrolysing)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.079 - 0.121
1,3,7,9-tetramethyluric
0.067 - 0.07
1,3,7-trimethyluric acid
0.072 - 0.088
1,3-dimethyluric acid
0.113 - 0.119
1,7-dimethyluric acid
0.096 - 0.101
1-methyluric acid
0.33 - 0.42
2'-deoxy-GTP
0.33 - 0.45
2'-deoxy-guanosine
0.11 - 0.18
2,6-diaminopurine riboside
0.22 - 0.26
2-aminopurine riboside
0.34 - 0.4
3'-deoxy-guanosine
0.063 - 0.09
3,7-dimethyluric acid
0.39 - 0.61
6-thioguanine
0.23 - 0.4
6-thioguanosine
0.08 - 0.13
8-oxoguanosine
0.11 - 0.15
8-oxoguanosine 5'-triphosphate
0.33 - 0.49
acycloguanosine
0.31 - 0.41
acycloguanosine monophosphate
12.9 - 15.8
adenine
11 - 12
adenosine
0.39 - 0.51
Caffeine
0.04 - 0.32
CTP
0.29 - 0.41
dideoxy-GTP
0.29 - 0.33
GDP
0.23 - 0.33
GMP
0.29 - 0.46
GTP
0.22 - 0.38
guanosine
0.33 - 0.42
guanosine 5'-tetraphosphate
3.5 - 5.2
Inosine
2.9 - 4.1
ITP
0.17 - 0.23
N-methylguanosine
0.15 - 0.25
O-methylguanosine
0.44 - 0.48
paraxanthine
0.42 - 0.58
Theobromine
0.43 - 0.55
theophylline
4.2 - 4.7
Uracil
2.6 - 3.2
uracil-4-acetic acid
0.06 - 0.1
uric acid
3.1 - 4.6
uridine
0.23 - 0.37
xanthine
0.22 - 0.29
Xanthosine
additional information
additional information
Escherichia coli
-
xanthine and related compounds inhibit CTPS activity with IC50 = 0.16-0.58 mM. The presence of an 8-oxo function enhances the inhibition to IC50 = 0.060-0.121 mM. Raising the pH from 8.0 to 8.5 results in slightly increased inhibition of NH3-dependent CTP formation by the xanthines
-