6.3.4.2: CTP synthase (glutamine hydrolysing)
This is an abbreviated version!
For detailed information about CTP synthase (glutamine hydrolysing), go to the full flat file.
Word Map on EC 6.3.4.2
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6.3.4.2
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pyrimidine
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cytosine
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cytoophidia
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dctp
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cyclopentenyl
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deoxycytidine
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acivicin
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glutamine-dependent
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3-deazauridine
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rheumatology
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l-glutamine
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alliance
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carra
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ctpas
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pyrazofurin
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uridine-cytidine
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rheumatologist
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6-diazo-5-oxo-l-norleucine
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drug development
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medicine
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analysis
- 6.3.4.2
- pyrimidine
- cytosine
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cytoophidia
- dctp
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cyclopentenyl
- deoxycytidine
- acivicin
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glutamine-dependent
- 3-deazauridine
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rheumatology
- l-glutamine
-
alliance
-
carra
-
ctpas
- pyrazofurin
-
uridine-cytidine
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rheumatologist
- 6-diazo-5-oxo-l-norleucine
- drug development
- medicine
- analysis
Reaction
Synonyms
CTP synthase, CTP synthase 1, CTP synthetase, CTP synthetase 1, CTPS, CTPS1, CTPS2, CTPsyn, CTS, cytidine 5'-triphosphate synthase, cytidine 5'-triphosphate synthetase, cytidine triphosphate synthetase, cytidine triphosphate synthetase 1, EcCTPS, pfCTP synthetase, PyrG, synthetase, cytidine triphosphate, URA7, uridine triphosphate aminase, UTP-ammonia ligase, UTP:ammonia ligase (ADP-forming)
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Natural Substrates Products
Natural Substrates Products on EC 6.3.4.2 - CTP synthase (glutamine hydrolysing)
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REACTION DIAGRAM
ATP + UTP + NH4+
ADP + phosphate + CTP
last step in CTP biosynthesis
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UTP + ATP + NH3
CTP + ADP + phosphate
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the enzyme is regulated in a complex fashion, overview
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ADP + phosphate + CTP + L-glutamate
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the CTPS1-encoded enzyme is regulated by reversible phosphorylation at Thr455, regulation mechanisms, overview
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ATP + UTP + glutamine
ADP + phosphate + CTP + L-glutamate
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CTP synthetase is a cytosolic-associated glutamine amidotransferase enzyme that catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP to form CTP. CTP is an essential precursor of all membrane phospholipids that are synthesized via the Kennedy, i.e. CDP-choline and CDP-ethanolamine branches, and CDP-diacylglycerol pathways. The URA7-encoded CTP synthetase is responsible for the majority of the CTP made in vivo. Regulation mechanisms, detailed overview
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ADP + phosphate + CTP + L-glutamate
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ATP + UTP + L-glutamine
ADP + phosphate + CTP + L-glutamate
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ATP + UTP + NH3
ADP + phosphate + CTP
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CTPS1 is involved in microtubule network formation and/or stabilzation, overview
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repression of the pyrG gene encoding cytidine triphosphate synthetase is responsive to cytidine nucleotide levels and is independent of both uridine nucleotides and PyrR-dependent attenuation
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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additional information
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key enzyme for biosynthesis of cytosine ribonucleotides
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additional information
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the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways
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additional information
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rate-limiting enzyme in the synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways. In human lymphoblastic leukemia cells the synthesis of CTP occurs predominantly via CTP synthetase, whereas in proliferating normal human T lymphocytes the salvage of cytidine is preferred
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additional information
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the enzyme is one of the key enzymes in pyrimidine nucleotide anabolic pathways. The activity of this enzyme is elevated in various malignancies including acute lymphocytic leukemia
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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additional information
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CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed
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additional information
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in Lactococcus lactis the pyrG gene product is the only enzyme responsible for the amination of UTP to CTP
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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additional information
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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-
?
additional information
?
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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-
?
additional information
?
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CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
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?
additional information
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regulation of CTP synthetase activity by CTP plays an important role in the regulation of phospholipid synthesis
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additional information
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the enzyme is allosterically regulated by CTP product inhibition and by reversible phosphorylation
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