6.3.4.2: CTP synthase (glutamine hydrolysing)
This is an abbreviated version!
For detailed information about CTP synthase (glutamine hydrolysing), go to the full flat file.
Word Map on EC 6.3.4.2
-
6.3.4.2
-
pyrimidine
-
cytosine
-
cytoophidia
-
dctp
-
cyclopentenyl
-
deoxycytidine
-
acivicin
-
glutamine-dependent
-
3-deazauridine
-
rheumatology
-
l-glutamine
-
alliance
-
carra
-
ctpas
-
pyrazofurin
-
uridine-cytidine
-
rheumatologist
-
6-diazo-5-oxo-l-norleucine
-
drug development
-
medicine
-
analysis
- 6.3.4.2
- pyrimidine
- cytosine
-
cytoophidia
- dctp
-
cyclopentenyl
- deoxycytidine
- acivicin
-
glutamine-dependent
- 3-deazauridine
-
rheumatology
- l-glutamine
-
alliance
-
carra
-
ctpas
- pyrazofurin
-
uridine-cytidine
-
rheumatologist
- 6-diazo-5-oxo-l-norleucine
- drug development
- medicine
- analysis
Reaction
Synonyms
CTP synthase, CTP synthase 1, CTP synthetase, CTP synthetase 1, CTPS, CTPS1, CTPS2, CTPsyn, CTS, cytidine 5'-triphosphate synthase, cytidine 5'-triphosphate synthetase, cytidine triphosphate synthetase, cytidine triphosphate synthetase 1, EcCTPS, pfCTP synthetase, PyrG, synthetase, cytidine triphosphate, URA7, uridine triphosphate aminase, UTP-ammonia ligase, UTP:ammonia ligase (ADP-forming)
ECTree
6.3.4.2 CTP synthase (glutamine hydrolysing)Advanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 6.3.4.2 - CTP synthase (glutamine hydrolysing)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + UTP + NH4+
ADP + phosphate + CTP
last step in CTP biosynthesis
-
-
?
UTP + ATP + NH3
CTP + ADP + phosphate
-
the enzyme is regulated in a complex fashion, overview
-
-
?
ATP + UTP + glutamine
ADP + phosphate + CTP + L-glutamate
-
the CTPS1-encoded enzyme is regulated by reversible phosphorylation at Thr455, regulation mechanisms, overview
-
-
?
ATP + UTP + glutamine
ADP + phosphate + CTP + L-glutamate
-
CTP synthetase is a cytosolic-associated glutamine amidotransferase enzyme that catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP to form CTP. CTP is an essential precursor of all membrane phospholipids that are synthesized via the Kennedy, i.e. CDP-choline and CDP-ethanolamine branches, and CDP-diacylglycerol pathways. The URA7-encoded CTP synthetase is responsible for the majority of the CTP made in vivo. Regulation mechanisms, detailed overview
-
-
?
ATP + UTP + L-glutamine
ADP + phosphate + CTP + L-glutamate
-
-
-
-
?
ATP + UTP + L-glutamine
ADP + phosphate + CTP + L-glutamate
-
-
-
?
ATP + UTP + NH3
ADP + phosphate + CTP
-
CTPS1 is involved in microtubule network formation and/or stabilzation, overview
-
-
?
additional information
?
-
-
repression of the pyrG gene encoding cytidine triphosphate synthetase is responsive to cytidine nucleotide levels and is independent of both uridine nucleotides and PyrR-dependent attenuation
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
-
key enzyme for biosynthesis of cytosine ribonucleotides
-
-
?
additional information
?
-
-
the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways
-
-
?
additional information
?
-
-
rate-limiting enzyme in the synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways. In human lymphoblastic leukemia cells the synthesis of CTP occurs predominantly via CTP synthetase, whereas in proliferating normal human T lymphocytes the salvage of cytidine is preferred
-
-
?
additional information
?
-
-
the enzyme is one of the key enzymes in pyrimidine nucleotide anabolic pathways. The activity of this enzyme is elevated in various malignancies including acute lymphocytic leukemia
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
-
CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed
-
-
?
additional information
?
-
-
in Lactococcus lactis the pyrG gene product is the only enzyme responsible for the amination of UTP to CTP
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP
-
-
?
additional information
?
-
-
regulation of CTP synthetase activity by CTP plays an important role in the regulation of phospholipid synthesis
-
-
?
additional information
?
-
-
the enzyme is allosterically regulated by CTP product inhibition and by reversible phosphorylation
-
-
?
