6.3.4.2: CTP synthase (glutamine hydrolysing)
This is an abbreviated version!
For detailed information about CTP synthase (glutamine hydrolysing), go to the full flat file.
Word Map on EC 6.3.4.2
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6.3.4.2
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pyrimidine
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cytosine
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cytoophidia
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dctp
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cyclopentenyl
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deoxycytidine
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acivicin
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glutamine-dependent
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3-deazauridine
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rheumatology
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l-glutamine
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alliance
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carra
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ctpas
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pyrazofurin
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uridine-cytidine
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rheumatologist
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6-diazo-5-oxo-l-norleucine
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drug development
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medicine
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analysis
- 6.3.4.2
- pyrimidine
- cytosine
-
cytoophidia
- dctp
-
cyclopentenyl
- deoxycytidine
- acivicin
-
glutamine-dependent
- 3-deazauridine
-
rheumatology
- l-glutamine
-
alliance
-
carra
-
ctpas
- pyrazofurin
-
uridine-cytidine
-
rheumatologist
- 6-diazo-5-oxo-l-norleucine
- drug development
- medicine
- analysis
Reaction
Synonyms
CTP synthase, CTP synthase 1, CTP synthetase, CTP synthetase 1, CTPS, CTPS1, CTPS2, CTPsyn, CTS, cytidine 5'-triphosphate synthase, cytidine 5'-triphosphate synthetase, cytidine triphosphate synthetase, cytidine triphosphate synthetase 1, EcCTPS, pfCTP synthetase, PyrG, synthetase, cytidine triphosphate, URA7, uridine triphosphate aminase, UTP-ammonia ligase, UTP:ammonia ligase (ADP-forming)
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Application on EC 6.3.4.2 - CTP synthase (glutamine hydrolysing)
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drug development
medicine
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daily injection of acivicin in trypanosome-infected mice suppresses the infection up to one month without any significant loss of weight. Experiments with cultured bloodstream Trypanosoma brucei shows that acivicin is trypanocidal if present at 0.001 nM concentration for at least 4 d. Acivicin may qualify as a drug with desirable properties, i.e. cure within 7 d, according to the current Target Product Profiles of WHO and DNDi
drug development
modifying 2-aminopurine or 2-aminopurine riboside may serve as an effective strategy for developing CTPS inhibitors
drug development
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structure serves as a basis for structure-based design of anti-proliferative inhibitors
drug development
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CTP is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents
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the enzyme is an target for treatment of African sleeping sickness because the trypanosomes, unlike mammalian cells, cannot compensate for the inhibition of CTP synthetase by the salvage of cytidine. The CTP synthetase inhibitors 6-diazo-5-oxo-L-norleucine and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid reduce the parasite CTP level even further and inhibit trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice
medicine
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glutamine deficiency induces CTPS cytoophidia in human Huh-7 cells. CTPS cytoophidia are found in various human cancers and some noncancerous tissues. Among 203 tissue samples of hepatocellular carcinoma, 28% exhibited many cytoophidia, whereas no cytoophidia are detected in adjacent noncancerous hepatocytes for all samples