6.3.4.2: CTP synthase (glutamine hydrolysing)
This is an abbreviated version!
For detailed information about CTP synthase (glutamine hydrolysing), go to the full flat file.
Word Map on EC 6.3.4.2
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6.3.4.2
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pyrimidine
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cytosine
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cytoophidia
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dctp
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cyclopentenyl
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deoxycytidine
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acivicin
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glutamine-dependent
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3-deazauridine
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rheumatology
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l-glutamine
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alliance
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carra
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ctpas
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pyrazofurin
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uridine-cytidine
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rheumatologist
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6-diazo-5-oxo-l-norleucine
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drug development
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medicine
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analysis
- 6.3.4.2
- pyrimidine
- cytosine
-
cytoophidia
- dctp
-
cyclopentenyl
- deoxycytidine
- acivicin
-
glutamine-dependent
- 3-deazauridine
-
rheumatology
- l-glutamine
-
alliance
-
carra
-
ctpas
- pyrazofurin
-
uridine-cytidine
-
rheumatologist
- 6-diazo-5-oxo-l-norleucine
- drug development
- medicine
- analysis
Reaction
Synonyms
CTP synthase, CTP synthase 1, CTP synthetase, CTP synthetase 1, CTPS, CTPS1, CTPS2, CTPsyn, CTS, cytidine 5'-triphosphate synthase, cytidine 5'-triphosphate synthetase, cytidine triphosphate synthetase, cytidine triphosphate synthetase 1, EcCTPS, pfCTP synthetase, PyrG, synthetase, cytidine triphosphate, URA7, uridine triphosphate aminase, UTP-ammonia ligase, UTP:ammonia ligase (ADP-forming)
ECTree
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KI Value
KI Value on EC 6.3.4.2 - CTP synthase (glutamine hydrolysing)
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0.33
1-beta-D-ribofuranosyl-2-thiouracil 5'-triphosphate
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pH 7.2, inhibition of glutamine reaction
0.08
2-Thiocytidine 5'-triphosphate
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pH 7.2, inhibition of glutamine reaction and ammonia reaction
0.182
Gln
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30°C, pH 8.0, inhibition of hydroxylamine-dependent N4-OH CTP synthesis in presence of GTP
3.36
in the presence of 10 mM UTP
3.7
2',3'-dialdehyde adenosine 5'-triphosphate
K306A: replacement of lysine 306 by alanine reduces the rate of 2',3'-dialdehyde adenosine 5'-triphosphate-dependent inactivation
0.1
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pH 7.2, inhibition of glutamine reaction
0.25
2-thiouridine 5'-triphosphate
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pH 7.2, inhibition of ammonia reaction
additional information
additional information
no saturation kinetic is obtained with S-nitroso-L-homocysteine
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additional information
additional information
nucleotide and nucleoside analogues of GTP and guanosine, respectively, all inhibit NH3- and Gln-dependent CTP formation to a similar extent (IC50 : 0.20.5 mM). This inhibition appears to be due solely to the purine base and is relatively insensitive to the identity of the purine with the exception of inosine, ITP, and adenosine (IC50 : 412 mM). 8-Oxoguanosine is the best inhibitor identified (IC50 : 0.08 mM).
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additional information
additional information
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nucleotide and nucleoside analogues of GTP and guanosine, respectively, all inhibit NH3- and Gln-dependent CTP formation to a similar extent (IC50 : 0.20.5 mM). This inhibition appears to be due solely to the purine base and is relatively insensitive to the identity of the purine with the exception of inosine, ITP, and adenosine (IC50 : 412 mM). 8-Oxoguanosine is the best inhibitor identified (IC50 : 0.08 mM).
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additional information
additional information
kinetic mechanism, activation and inhibition kinetics
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additional information
additional information
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kinetic mechanism, activation and inhibition kinetics
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additional information
additional information
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inhibition kinetics. Multisite inhibition of CTPS-catalyzed NH3-dependent CTP formation by caffeine
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