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6.3.2.4: D-Alanine-D-alanine ligase

This is an abbreviated version!
For detailed information about D-Alanine-D-alanine ligase, go to the full flat file.

Word Map on EC 6.3.2.4

Reaction

ATP
+ 2 D-alanine =
ADP
 +
phosphate
 +
D-alanyl-D-alanine

Synonyms

AbDDL, ATP-dependent D-Ala:D-Ala ligase, BBR47_20440, BMD_0213, BMQ_0219, BMWSH_5013, D-Ala-D-Ala ligase, D-Ala-D-Ala synthetase, D-Ala:D-Ala ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-Alanine:D-alanine ligase, D-alanyl-D-alanine ligase B, D-Alanyl-D-alanine synthetase, D-Alanylalanine synthetase, DD1, DDI, Ddl, DdlA, DdlB, DdlB ligase, dll, dllB, EcDdlB, More, Rv2981c, SsDdl, Synthetase, D-alanylalanine, Tb-DdlA, TmDdl, TtDdL, TTHA1587, VanA, VanB ligase, YpDDL

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.4 D-Alanine-D-alanine ligase

Substrates Products

Substrates Products on EC 6.3.2.4 - D-Alanine-D-alanine ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2 D-Ala
ADP + phosphate + D-Ala-D-Ala
show the reaction diagram
ATP + 2 D-alanine
ADP + phosphate + D-alanyl-D-alanine
show the reaction diagram
ATP + Ala + Ala
?
show the reaction diagram
ATP + beta-Ala
ADP + phosphate + ?
show the reaction diagram
at 60°C activity is 1.3% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Ala + 2-aminopentanoate
ADP + phosphate + D-Ala-2-aminopentanoate
show the reaction diagram
-
-
-
-
?
ATP + D-Ala + 2-hydroxybutanoate
ADP + phosphate + D-Ala-D-2-hydroxybutanoate
show the reaction diagram
-
-
-
?
ATP + D-Ala + 2-hydroxypentanoate
ADP + phosphate + D-Ala-D-2-hydroxypentanoate
show the reaction diagram
-
-
-
?
ATP + D-Ala + D-2-aminopentanoate
ADP + phosphate + D-Ala-D-2-aminopentanoate
show the reaction diagram
ATP + D-Ala + D-Ala
ADP + phosphate + D-Ala-D-Ala
show the reaction diagram
ATP + D-Ala + D-lactate
ADP + phosphate + D-Ala-D-lactate
show the reaction diagram
ATP + D-Ala + D-Met
ADP + phosphate + D-Ala-D-Met
show the reaction diagram
ATP + D-Ala + D-norleucine
ADP + phosphate + D-Ala-D-norleucine
show the reaction diagram
ATP + D-Ala + D-Phe
ADP + phosphate + D-Ala-D-Phe
show the reaction diagram
ATP + D-Ala + NH3
ADP + phosphate + D-AlaNH2
show the reaction diagram
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
show the reaction diagram
ATP + D-alanine + D-serine
ADP + D-alanyl-D-serine + D-alanyl-D-alanine + D-seryl-D-serine
show the reaction diagram
ATP + D-Arg
ADP + phosphate + D-Arg-D-Arg
show the reaction diagram
at 60°C activity is 0.43% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Asn
ADP + phosphate + D-Asn-D-Asn
show the reaction diagram
at 60°C activity is 0.22% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Asp
ADP + phosphate + D-Asp-D-Asp
show the reaction diagram
at 60°C activity is 0.051% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Cys
ADP + phosphate + D-Cys-D-Cys
show the reaction diagram
at 60°C activity is 29% of the activity with D-Ala
-
-
?
ATP + D-Gln
ADP + phosphate + D-Gln-D-Gln
show the reaction diagram
at 60°C activity is 0.56% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Glu
ADP + phosphate + D-Glu-D-Glu
show the reaction diagram
at 60°C activity is 0.012% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-His
ADP + phosphate + D-His-D-His
show the reaction diagram
at 60°C activity is 0.49% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Ile
ADP + phosphate + D-Ile-D-Ile
show the reaction diagram
at 60°C activity is 0.36% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Leu
ADP + phosphate + D-Leu-D-Leu
show the reaction diagram
at 60°C activity is 0.31% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Lys
ADP + phosphate + D-Lys-D-Lys
show the reaction diagram
at 60°C activity is 0.6% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Met
ADP + phosphate + D-Met-D-Met
show the reaction diagram
at 60°C activity is 0.34% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Phe
ADP + phosphate + D-Phe-D-Phe
show the reaction diagram
at 60°C activity is 0.31% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Pro
ADP + phosphate + D-Pro-D-Pro
show the reaction diagram
at 60°C activity is 0.29% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Ser
ADP + phosphate + D-Ser-D-Ser
show the reaction diagram
at 60°C activity is 16% of the activity with D-Ala
-
-
?
ATP + D-serine
ADP + phosphate + D-alanyl-D-serine
show the reaction diagram
-
-
-
?
ATP + D-Thr
ADP + phosphate + D-Thr-D-Thr
show the reaction diagram
at 60°C activity is 2.2% of the activity with D-Ala
-
-
?
ATP + D-Trp
ADP + phosphate + D-Trp-D-Trp
show the reaction diagram
at 60°C activity is 0.1% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + D-Val
ADP + phosphate + D-Val-D-Val
show the reaction diagram
at 60°C activity is 0.43% of the activity with D-Ala, no activity at 37°C
-
-
?
ATP + Gly
ADP + phosphate + Gly-Gly
show the reaction diagram
at 60°C activity is 3.6% of the activity with D-Ala
-
-
?
beta-alanine + beta-alanine + ATP
beta-alanyl-beta-alanine + ADP + phosphate
show the reaction diagram
-
1.3% of the activity with D-serine
-
?
D-alanine + D-alanine + ATP
D-alanyl-D-alanine + ADP + phosphate
show the reaction diagram
-
-
-
?
D-cycloserine
?
show the reaction diagram
D-cysteine + ATP
ADP + D-cysteinyl-D-cysteine
show the reaction diagram
D-cysteine + D-cysteine + ATP
D-cysteinyl-D-cysteine + ADP + phosphate
show the reaction diagram
-
29% of the activity with D-serine
-
?
D-serine + ATP
ADP + D-serinyl-D-serine
show the reaction diagram
D-serine + D-serine + ATP
D-seryl-D-serine + ADP + phosphate
show the reaction diagram
-
16% of the activity with D-serine
-
?
D-threonine + ATP
ADP + D-threonyl-D-threonine
show the reaction diagram
D-threonine + D-threonine + ATP
D-threonyl-D-threonine + ADP + phosphate
show the reaction diagram
-
2.2% of the activity with D-serine
-
?
dipeptides + ATP
?
show the reaction diagram
glycine + D-alanine + ATP
glycyl-D-alanine + ADP + phosphate
show the reaction diagram
-
3.6% of the activity with D-serine
-
?
glycine + glycine + ATP
ADP + Gly-Gly + phosphate
show the reaction diagram
additional information
?
-