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Literature summary for 6.3.2.4 extracted from

  • Sova, M.; Cadez, G.; Turk, S.; Majce, V.; Polanc, S.; Batson, S.; Lloyd, A.J.; Roper, D.I.; Fishwick, C.W.; Gobec, S.
    Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB) (2009), Bioorg. Med. Chem. Lett., 19, 1376-1379.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 75% inhibition Enterococcus faecium
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 77% inhibition Escherichia coli
1-[[(4-fluorophenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl phenyl hydrogen phosphate 0.5 mM, 65% inhibition Enterococcus faecium
1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 83% inhibition Enterococcus faecium
1-[[(4-methoxyphenyl)sulfonyl]amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate 0.5 mM, 83% inhibition Escherichia coli

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
isoform VanA
-
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2 D-Ala
-
Escherichia coli ADP + phosphate + D-Ala-D-Ala
-
?
ATP + 2 D-Ala
-
Enterococcus faecium ADP + phosphate + D-Ala-D-Ala
-
?
ATP + D-Ala + D-lactate enzyme uses both D-Ala and D-lactate as a substrate Enterococcus faecium ADP + phosphate + D-Ala-D-lactate
-
?