6.3.2.4: D-Alanine-D-alanine ligase
This is an abbreviated version!
For detailed information about D-Alanine-D-alanine ligase, go to the full flat file.
Word Map on EC 6.3.2.4
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6.3.2.4
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peptidoglycan
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vancomycin
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enterococci
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d-cycloserine
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vancomycin-resistant
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faecium
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d-alanyl-d-lactate
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teicoplanin
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depsipeptide
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d-ala-d-lac
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drug development
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vanrs
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atp-grasp
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vancomycin-dependent
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vand-type
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d-ala-d-lactate
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d-ala2
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analysis
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synthesis
- 6.3.2.4
- peptidoglycan
- vancomycin
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enterococci
- d-cycloserine
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vancomycin-resistant
- faecium
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d-alanyl-d-lactate
- teicoplanin
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depsipeptide
- d-ala-d-lac
- drug development
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vanrs
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atp-grasp
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vancomycin-dependent
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vand-type
- d-ala-d-lactate
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d-ala2
- analysis
- synthesis
Reaction
Synonyms
AbDDL, ATP-dependent D-Ala:D-Ala ligase, BBR47_20440, BMD_0213, BMQ_0219, BMWSH_5013, D-Ala-D-Ala ligase, D-Ala-D-Ala synthetase, D-Ala:D-Ala ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-Alanine:D-alanine ligase, D-alanyl-D-alanine ligase B, D-Alanyl-D-alanine synthetase, D-Alanylalanine synthetase, DD1, DDI, Ddl, DdlA, DdlB, DdlB ligase, dll, dllB, EcDdlB, More, Rv2981c, SsDdl, Synthetase, D-alanylalanine, Tb-DdlA, TmDdl, TtDdL, TTHA1587, VanA, VanB ligase, YpDDL
ECTree
6.3.2.4 D-Alanine-D-alanine ligaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.3.2.4 - D-Alanine-D-alanine ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 2 D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
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?
ATP + 2 D-alanine
ADP + phosphate + D-alanyl-D-alanine
Mycobacterium tuberculosis ATCC 25618 / H37Rv
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-
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?
ATP + 2 D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
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?
ATP + 2 D-alanine
ADP + phosphate + D-alanyl-D-alanine
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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-
-
?
ATP + Ala + Ala
?
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the finding that the reactions of EC 6.3.2.4 and EC 6.3.2.10 are reversible may represent a functional regulatory mechanism which determines the level of the lysine-containing UDPMurNAc-pentapeptide depending on the intracellular ATP/ADP ratio
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-
?
ATP + Ala + Ala
?
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second step in the biosynthesis of bacterial peptidoglycan
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-
?
ATP + Ala + Ala
?
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a possible cellular role of VanA is to synthesize a modified cell-wall component, with D-Ala-D-Met or D-Ala-Phe instead of D-Ala-D-Ala, which is subsequently not recognized by vancomycin
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?
ATP + Ala + Ala
?
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enzyme involved in peptidoglycan precursor synthesis during sporulation
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-
?
ATP + Ala + Ala
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enzyme involved in peptidoglycan precursor synthesis during sporulation
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-
?
ATP + Ala + Ala
?
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one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide
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-
?
ATP + Ala + Ala
?
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second enzyme in the three enzyme D-alanine branch of peptidoglycan biosynthesis
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-
?
ATP + Ala + Ala
?
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the finding that the reactions of EC 6.3.2.4 and EC 6.3.2.10 are reversible may represent a functional regulatory mechanism which determines the level of the lysine-containing UDPMurNAc-pentapeptide depending on the intracellular ATP/ADP ratio
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-
?
ATP + Ala + Ala
?
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one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide
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-
?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
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essential enzyme
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?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
-
?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
-
?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
-
-
?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
D-alanine:D-alanine ligase is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics
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?
ATP + D-alanine
ADP + phosphate + D-alanyl-D-alanine
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-
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?
additional information
?
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DDl is an essential enzyme in bacterial cell wall biosynthesis
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?
additional information
?
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putative protein interaction partners of enzyme DdlA from Mycobacterium tuberculosis, overview
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?
additional information
?
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putative protein interaction partners of enzyme DdlA from Mycobacterium tuberculosis, overview
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?
additional information
?
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Mycobacterium tuberculosis ATCC 25618 / H37Rv
putative protein interaction partners of enzyme DdlA from Mycobacterium tuberculosis, overview
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?
