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6.3.2.4: D-Alanine-D-alanine ligase

This is an abbreviated version!
For detailed information about D-Alanine-D-alanine ligase, go to the full flat file.

Word Map on EC 6.3.2.4

Reaction

ATP
+ 2 D-alanine =
ADP
+
phosphate
+
D-alanyl-D-alanine

Synonyms

AbDDL, ATP-dependent D-Ala:D-Ala ligase, BBR47_20440, BMD_0213, BMQ_0219, BMWSH_5013, D-Ala-D-Ala ligase, D-Ala-D-Ala synthetase, D-Ala:D-Ala ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-Alanine:D-alanine ligase, D-alanyl-D-alanine ligase B, D-Alanyl-D-alanine synthetase, D-Alanylalanine synthetase, DD1, DDI, Ddl, DdlA, DdlB, DdlB ligase, dll, dllB, EcDdlB, More, Rv2981c, SsDdl, Synthetase, D-alanylalanine, Tb-DdlA, TmDdl, TtDdL, TTHA1587, VanA, VanB ligase, YpDDL

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.2 Acid—amino-acid ligases (peptide synthases)
                6.3.2.4 D-Alanine-D-alanine ligase

Expression

Expression on EC 6.3.2.4 - D-Alanine-D-alanine ligase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
presence of transcriptional coupling between ddlB gene associated with peptidoglycan biosynthesis and the fts genes required to control cell division
-
transcription factor DdlR is an activator of the ddlR-ddl operon, overview. Purified Ddl belongs to the belong to the MocR/GabR family, and is a pyridoxal 5'-phosphate binding transcriptional regulator that has dipeptide binding ability for D-alanyl-D-alanine, the enzymatic product of Ddl, and glycylglycine. DdlR is capable of forming a dipeptide-pyridoxal 5'-phosphate external aldimine, but it lacks aminotransferase activity