6.3.2.4: D-Alanine-D-alanine ligase

This is an abbreviated version!
For detailed information about D-Alanine-D-alanine ligase, go to the full flat file.

Word Map on EC 6.3.2.4

6.3.2.4

peptidoglycan

vancomycin

enterococci

d-cycloserine

vancomycin-resistant

faecium

d-alanyl-d-lactate

teicoplanin

depsipeptide

d-ala-d-lac

drug development

vanrs

atp-grasp

vancomycin-dependent

vand-type

d-ala-d-lactate

d-ala2

analysis

synthesis

Reaction

+ 2 D-alanine =

Synonyms

AbDDL, ATP-dependent D-Ala:D-Ala ligase, BBR47_20440, BMD_0213, BMQ_0219, BMWSH_5013, D-Ala-D-Ala ligase, D-Ala-D-Ala synthetase, D-Ala:D-Ala ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-Alanine:D-alanine ligase, D-alanyl-D-alanine ligase B, D-Alanyl-D-alanine synthetase, D-Alanylalanine synthetase, DD1, DDI, Ddl, DdlA, DdlB, DdlB ligase, dll, dllB, EcDdlB, More, Rv2981c, SsDdl, Synthetase, D-alanylalanine, Tb-DdlA, TmDdl, TtDdL, TTHA1587, VanA, VanB ligase, YpDDL

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.4 D-Alanine-D-alanine ligase

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Results	in table
2	Activating Compound
46866	AA Sequence
10	Application
1	CAS Registry Number
31	Cloned(Commentary)
14	Cofactor
15	Crystallization (Commentary)
3	Expression
25	General Information
48	IC50 Value
247	Inhibitors
17	kcat/KM [mM/s]
21	Ki Value [mM]
99	KM Value [mM]
13	Metals/Ions
3	Molecular Weight [Da]
45	Natural Substrates/ Products (Substrates)
399	Organism
8	Pathway
148	PDB ID
11	pH Optimum
2	pH Range
51	Protein Variants
20	Purification (Commentary)
4	Reaction
2	Reaction Type
92	Reference
4	Source Tissue
21	Specific Activity [micromol/min/mg]
167	Substrates and Products (Substrate)
15	Subunits
91	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
32	Turnover Number [1/s]

pH Range

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pH Range on EC 6.3.2.4 - D-Alanine-D-alanine ligase

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6 - 9.2

Streptomyces lavendulae

higher DDL activity at pH 9.2 than at pH 6.0-7.5

662288

additional information

2 entries