6.3.2.4: D-Alanine-D-alanine ligase
This is an abbreviated version!
For detailed information about D-Alanine-D-alanine ligase, go to the full flat file.
Word Map on EC 6.3.2.4
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6.3.2.4
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peptidoglycan
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vancomycin
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enterococci
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d-cycloserine
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vancomycin-resistant
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faecium
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d-alanyl-d-lactate
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teicoplanin
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depsipeptide
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d-ala-d-lac
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drug development
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vanrs
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atp-grasp
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vancomycin-dependent
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vand-type
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d-ala-d-lactate
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d-ala2
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analysis
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synthesis
- 6.3.2.4
- peptidoglycan
- vancomycin
-
enterococci
- d-cycloserine
-
vancomycin-resistant
- faecium
-
d-alanyl-d-lactate
- teicoplanin
-
depsipeptide
- d-ala-d-lac
- drug development
-
vanrs
-
atp-grasp
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vancomycin-dependent
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vand-type
- d-ala-d-lactate
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d-ala2
- analysis
- synthesis
Reaction
Synonyms
AbDDL, ATP-dependent D-Ala:D-Ala ligase, BBR47_20440, BMD_0213, BMQ_0219, BMWSH_5013, D-Ala-D-Ala ligase, D-Ala-D-Ala synthetase, D-Ala:D-Ala ligase, D-alanine:D-alanine (D-lactate) ligase (ADP), D-Alanine:D-alanine ligase, D-alanyl-D-alanine ligase B, D-Alanyl-D-alanine synthetase, D-Alanylalanine synthetase, DD1, DDI, Ddl, DdlA, DdlB, DdlB ligase, dll, dllB, EcDdlB, More, Rv2981c, SsDdl, Synthetase, D-alanylalanine, Tb-DdlA, TmDdl, TtDdL, TTHA1587, VanA, VanB ligase, YpDDL
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Reaction
Reaction on EC 6.3.2.4 - D-Alanine-D-alanine ligase
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ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
reaction mechanism via tetrahedral reaction intermediate, overview
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ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
first, the ATP-dependent dimerization reactions catalyzed by DdlA proceed through the phosphorylation of the D-alanine at the carboxyl group by the gamma-phosphate of ATP to produce an acylphosphate intermediate. Then, a tetrahedral intermediate is formed by the nucleophilic attacking of the amino nitrogen of the second D-alanine on the acylphosphate intermediate. Finally, a phosphate group is released from the tetrahedral intermediate to generate the final product of D-alanyl-D-alanine
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
first, the ATP-dependent dimerization reactions catalyzed by DdlA proceed through the phosphorylation of the D-alanine at the carboxyl group by the gamma-phosphate of ATP to produce an acylphosphate intermediate. Then, a tetrahedral intermediate is formed by the nucleophilic attacking of the amino nitrogen of the second D-alanine on the acylphosphate intermediate. Finally, a phosphate group is released from the tetrahedral intermediate to generate the final product of D-alanyl-D-alanine
Mycobacterium tuberculosis ATCC 25618 / H37Rv
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