6.3.1.20: lipoate-protein ligase
This is an abbreviated version!
For detailed information about lipoate-protein ligase, go to the full flat file.
Word Map on EC 6.3.1.20
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6.3.1.20
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lipoylation
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ligases
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octanoyl-acyl
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lipoate-dependent
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apicoplast
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octanoylation
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2-oxoacids
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lipoyl-amp
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octanoic
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bioorthogonal
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lipoyltransferase
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h-protein
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octanoyltransferase
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13-amino
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biotechnology
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synthesis
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molecular biology
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drug development
- 6.3.1.20
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lipoylation
- ligases
-
octanoyl-acyl
-
lipoate-dependent
- apicoplast
-
octanoylation
- 2-oxoacids
- lipoyl-amp
-
octanoic
-
bioorthogonal
- lipoyltransferase
- h-protein
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octanoyltransferase
-
13-amino
- biotechnology
- synthesis
- molecular biology
- drug development
Reaction
Synonyms
CTD, EC 2.7.7.63, LIP3, LipB, LipL1, lipoate ligase, lipoate ligase like protein, lipoate protein ligase, lipoate protein ligase B, lipoate-bound lipoate ligase 1, lipoate-protein ligase, lipoate-protein ligase A, lipoic acid ligase, lipoic acid ligase A, lipoic acid protein ligase, lipoic acid protein ligase A1, lipoyl ligase, lipoyl-protein ligase A, LPLA, LplA-LplB complex, LplA1, LplA1Ct, Lpla2, LplB, Oryza s. lipoate-protein ligase A, OsLPLA, PfLipL1
ECTree
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Reaction
Reaction on EC 6.3.1.20 - lipoate-protein ligase
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ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP
(1b)
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ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
overall reaction
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ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
LplA structures are determined: LplA/lipoyl-AMP binary complex and LplA/octyl-5'-AMP/apoH-protein ternary complex. These structures represent a post-lipoate adenylation stage and a pre-lipoate transfer stage, respectively. Three large scale conformational changes in the Escherichia coli LplA structure upon completion of the lipoate adenylation reaction are found, which enable LplA to accommodate apoprotein for the second reaction