6.3.1.20: lipoate-protein ligase

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For detailed information about lipoate-protein ligase, go to the full flat file.

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Synonyms

CTD, EC 2.7.7.63, LIP3, LipB, LipL1, lipoate ligase, lipoate ligase like protein, lipoate protein ligase, lipoate protein ligase B, lipoate-bound lipoate ligase 1, lipoate-protein ligase, lipoate-protein ligase A, lipoic acid ligase, lipoic acid ligase A, lipoic acid protein ligase, lipoic acid protein ligase A1, lipoyl ligase, lipoyl-protein ligase A, LPLA, LplA-LplB complex, LplA1, LplA1Ct, Lpla2, LplB, Oryza s. lipoate-protein ligase A, OsLPLA, PfLipL1

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

                6.3.1.20 lipoate-protein ligase

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Results	in table
1	Activating Compound
10845	AA Sequence
5	Application
1	CAS Registry Number
14	Cloned(Commentary)
8	Cofactor
5	Crystallization (Commentary)
15	Disease/ Diagnostics
2	Expression
16	General Information
15	Inhibitors
4	kcat/KM [mM/s]
19	KM Value [mM]
10	Localization
18	Metals/Ions
13	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
43	Organism
1	Oxidation Stability
5	Pathway
2	PDB ID
4	pH Optimum
1	pH Range
2	pI Value
29	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
35	Reference
1	Renatured (Commentary)
8	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
71	Substrates and Products (Substrate)
8	Subunits
63	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Disease

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Disease on EC 6.3.1.20 - lipoate-protein ligase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Infections

Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite.

28655332

Infections

Increased flexibility in the use of exogenous lipoic acid by Staphylococcus aureus.

29660187

Malaria

Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite.

28655332

Malaria

Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival.

19434237

Pneumococcal Infections

Immunization with a combination of three pneumococcal proteins confers additive and broad protection against Streptococcus pneumoniae Infections in Mice.

20038538

Sepsis

Streptococcus pneumoniae: proteomics of surface proteins for vaccine development.

18034862

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