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6.3.1.20: lipoate-protein ligase

This is an abbreviated version!
For detailed information about lipoate-protein ligase, go to the full flat file.

Word Map on EC 6.3.1.20

Reaction

ATP
+
(R)-lipoate
 +
a [lipoyl-carrier protein]-L-lysine
=
a [lipoyl-carrier protein]-N6-(lipoyl)lysine
 +
AMP
 +
diphosphate

Synonyms

CTD, EC 2.7.7.63, LIP3, LipB, LipL1, lipoate ligase, lipoate ligase like protein, lipoate protein ligase, lipoate protein ligase B, lipoate-bound lipoate ligase 1, lipoate-protein ligase, lipoate-protein ligase A, lipoic acid ligase, lipoic acid ligase A, lipoic acid protein ligase, lipoic acid protein ligase A1, lipoyl ligase, lipoyl-protein ligase A, LPLA, LplA-LplB complex, LplA1, LplA1Ct, Lpla2, LplB, Oryza s. lipoate-protein ligase A, OsLPLA, PfLipL1

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.20 lipoate-protein ligase

Reference

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Reference on EC 6.3.1.20 - lipoate-protein ligase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhao, X.; Miller, J.R.; Jiang, Y.; Marletta, M.A.; Cronan, J.E.
Assembly of the covalent linkage between lipoic acid and its cognate enzymes
Chem. Biol.
10
1293-1302
2003
Escherichia coli
Manually annotated by BRENDA team
Jordan, S.W.; Cronan, J.E.
A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli
J. Biol. Chem.
272
17903-17906
1997
Escherichia coli, Neurospora crassa
Manually annotated by BRENDA team
Green, D.E.; Morris, T.W.; Green, J.; Cronan, J.E., Jr.; Guest, J.R.
Purification and properties of the lipoate protein ligase of Escherichia coli
Biochem. J.
309
853-862
1995
Escherichia coli
Manually annotated by BRENDA team
Brookfield, D.E.; Green, J.; Ali, S.T.; Machado, R.S.; Guest, J.R.
Evidence for two protein-lipoylation activities in Escherichia coli
FEBS Lett.
295
13-16
1991
Escherichia coli
Manually annotated by BRENDA team
Morris, T.W.; Reed, K.E.; Cronan, J.E., Jr.
Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein
J. Bacteriol.
177
1-10
1995
Escherichia coli
Manually annotated by BRENDA team
Morris, T.W.; Reed, K.E.; Cronan, J.E., Jr.
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product
J. Biol. Chem.
269
16091-16100
1994
Escherichia coli (P32099), Escherichia coli
Manually annotated by BRENDA team
Fujiwara, K.; Toma, S.; Okamura-Ikeda, K.; Motokawa, Y.; Nakagawa, A.; Taniguchi, H.
Crystal structure of lipoate-protein ligase A from Escherichia coli. Determination of the lipoic acid-binding site
J. Biol. Chem.
280
33645-33651
2005
Escherichia coli
Manually annotated by BRENDA team
Kim do, J.; Kim, K.H.; Lee, H.H.; Lee, S.J.; Ha, J.Y.; Yoon, H.J.; Suh, S.W.
Crystal structure of lipoate-protein ligase A bound with the activated intermediate: insights into interaction with lipoyl domains
J. Biol. Chem.
280
38081-38089
2005
Thermoplasma acidophilum (Q9HKT1), Thermoplasma acidophilum
Manually annotated by BRENDA team
Allary, M.; Lu, J.Z.; Zhu, L.; Prigge, S.T.
Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum
Mol. Microbiol.
63
1331-1344
2007
Plasmodium falciparum
Manually annotated by BRENDA team
Ma, Q.; Zhao, X.; Nasser Eddine, A.; Geerlof, A.; Li, X.; Cronan, J.E.; Kaufmann, S.H.; Wilmanns, M.
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase
Proc. Natl. Acad. Sci. USA
103
8662-8667
2006
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Kang, S.G.; Jeong, H.K.; Lee, E.; Natarajan, S.
Characterization of a lipoate-protein ligase A gene of rice (Oryza sativa L.)
Gene
393
53-61
2007
Oryza sativa
Manually annotated by BRENDA team
Keeney, K.M.; Stuckey, J.A.; ORiordan, M.X.
LplA1-dependent utilization of host lipoyl peptides enables Listeria cytosolic growth and virulence
Mol. Microbiol.
66
758-770
2007
Listeria monocytogenes
Manually annotated by BRENDA team
Fujiwara, K.; Hosaka, H.; Nakagawa, A.; Motokawa, Y.
Lipoate-protein ligase A: Structure and function
Oxid. Stress Dis.
24
217-233
2008
Escherichia coli, Thermoplasma acidophilum
-
Manually annotated by BRENDA team
Posner, M.G.; Upadhyay, A.; Bagby, S.; Hough, D.W.; Danson, M.J.
A unique lipoylation system in the Archaea. Lipoylation in Thermoplasma acidophilum requires two proteins
FEBS J.
276
4012-4022
2009
Thermoplasma acidophilum (Q9HKT1), Thermoplasma acidophilum (Q9HKT2), Thermoplasma acidophilum
Manually annotated by BRENDA team
Puthenveetil, S.; Liu, D.S.; White, K.A.; Thompson, S.; Ting, A.Y.
Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase
J. Am. Chem. Soc.
131
16430-16438
2009
Escherichia coli
Manually annotated by BRENDA team
Hermes, F.A.; Cronan, J.E.
Scavenging of cytosolic octanoic acid by mutant LplA lipoate ligases allows growth of Escherichia coli strains lacking the LipB octanoyltransferase of lipoic acid synthesis
J. Bacteriol.
191
6796-6803
2009
Escherichia coli
Manually annotated by BRENDA team
Christensen, Q.H.; Cronan, J.E.
The Thermoplasma acidophilum LplA-LplB complex defines a new class of bipartite lipoate-protein ligases
J. Biol. Chem.
284
21317-21326
2009
Thermoplasma acidophilum (Q9HKT1), Thermoplasma acidophilum
Manually annotated by BRENDA team
Guenther, S.; Matuschewski, K.; Mueller, S.
Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival
PLoS ONE
4
e5510
2009
Plasmodium berghei, Plasmodium falciparum
Manually annotated by BRENDA team
Ramaswamy, A.V.; Maurelli, A.T.
Chlamydia trachomatis serovar L2 can utilize exogenous lipoic acid through the action of the lipoic acid ligase LplA1
J. Bacteriol.
192
6172-6181
2010
Chlamydia trachomatis
Manually annotated by BRENDA team
Fujiwara, K.; Maita, N.; Hosaka, H.; Okamura-Ikeda, K.; Nakagawa, A.; Taniguchi, H.
Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A
J. Biol. Chem.
285
9971-9980
2010
Escherichia coli (P32099), Escherichia coli
Manually annotated by BRENDA team
Cao, X.; Cronan, J.E.
The Streptomyces coelicolor lipoate-protein ligase is a circularly permuted version of the Escherichia coli enzyme composed of discrete interacting domains
J. Biol. Chem.
290
7280-7290
2015
Streptomyces coelicolor
Manually annotated by BRENDA team
Billones, J.; Carrillo, M.; Organo, V.; MacAlino, S.; Emnacen, I.; Sy, J.
Virtual screening against Mycobacterium tuberculosis lipoate protein ligase B (MtbLipB) and in Silico ADMET evaluation of top hits
Orient. J. Chem.
29
1457-1468
2013
Mycobacterium tuberculosis (P9WK83), Mycobacterium tuberculosis ATCC 25618 (P9WK83)
-
Manually annotated by BRENDA team
Ewald, R.; Hoffmann, C.; Florian, A.; Neuhaus, E.; Fernie, A.R.; Bauwe, H.
Lipoate-protein ligase and octanoyltransferase are essential for protein lipoylation in mitochondria of Arabidopsis
Plant Physiol.
165
978-990
2014
Arabidopsis thaliana
Manually annotated by BRENDA team
Hermes, F.A.; Cronan, J.E.
The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis
Yeast
30
415-427
2013
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Drake, C.R.; Sevillano, N.; Truillet, C.; Craik, C.S.; VanBrocklin, H.F.; Evans, M.J.
Site-specific radiofluorination of biomolecules with 8-[(18)F]-fluorooctanoic acid catalyzed by lipoic acid ligase
ACS Chem. Biol.
11
1587-1594
2016
Homo sapiens
Manually annotated by BRENDA team
Hauke, S.; Best, M.; Schmidt, T.T.; Baalmann, M.; Krause, A.; Wombacher, R.
Two-step protein labeling utilizing lipoic acid ligase and Sonogashira cross-coupling
Bioconjug. Chem.
25
1632-1637
2014
Escherichia coli
Manually annotated by BRENDA team
Best, M.; Degen, A.; Baalmann, M.; Schmidt, T.T.; Wombacher, R.
Two-step protein labeling by using lipoic acid ligase with norbornene substrates and subsequent inverse-electron demand Diels-Alder reaction
ChemBioChem
16
1158-1162
2015
Escherichia coli
Manually annotated by BRENDA team
Wang, M.; Wang, Q.; Gao, X.; Su, Z.
Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite
Parasit. Vectors
10
315
2017
Plasmodium berghei, Plasmodium berghei (A0A113RHS8), Plasmodium berghei ANKA, Plasmodium berghei ANKA (A0A113RHS8)
Manually annotated by BRENDA team
Guerra, A.; Afanador, G.; Prigge, S.
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum
Proteins
85
1777-1783
2017
Plasmodium falciparum (Q8IEG9), Plasmodium falciparum
Manually annotated by BRENDA team
Florian, P.; Petrareanu, G.; Ruta, S.; Roseanu, A.
Optimization of recombinant lipoic acid ligase expression from bacterial cells
Rom. Biotechnol. Lett.
21
11539-11542
2016
Escherichia coli (P32099)
-
Manually annotated by BRENDA team