6.3.1.20: lipoate-protein ligase

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For detailed information about lipoate-protein ligase, go to the full flat file.

Word Map on EC 6.3.1.20

6.3.1.20

lipoylation

ligases

octanoyl-acyl

lipoate-dependent

apicoplast

octanoylation

2-oxoacids

lipoyl-amp

octanoic

bioorthogonal

lipoyltransferase

h-protein

octanoyltransferase

13-amino

biotechnology

synthesis

molecular biology

drug development

Reaction

a [lipoyl-carrier protein]-N6-(lipoyl)lysine

Synonyms

CTD, EC 2.7.7.63, LIP3, LipB, LipL1, lipoate ligase, lipoate ligase like protein, lipoate protein ligase, lipoate protein ligase B, lipoate-bound lipoate ligase 1, lipoate-protein ligase, lipoate-protein ligase A, lipoic acid ligase, lipoic acid ligase A, lipoic acid protein ligase, lipoic acid protein ligase A1, lipoyl ligase, lipoyl-protein ligase A, LPLA, LplA-LplB complex, LplA1, LplA1Ct, Lpla2, LplB, Oryza s. lipoate-protein ligase A, OsLPLA, PfLipL1

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.1.20 lipoate-protein ligase

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Results	in table
1	Activating Compound
10845	AA Sequence
5	Application
1	CAS Registry Number
14	Cloned(Commentary)
8	Cofactor
5	Crystallization (Commentary)
15	Disease/ Diagnostics
2	Expression
16	General Information
15	Inhibitors
4	kcat/KM [mM/s]
19	KM Value [mM]
10	Localization
18	Metals/Ions
13	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
43	Organism
1	Oxidation Stability
5	Pathway
2	PDB ID
4	pH Optimum
1	pH Range
2	pI Value
29	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
35	Reference
1	Renatured (Commentary)
8	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
71	Substrates and Products (Substrate)
8	Subunits
63	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Expression

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Expression on EC 6.3.1.20 - lipoate-protein ligase

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although lplA1 mRNA expression is regulated tightly by anhydrotetracycline (ATc) during the whole course of infection, lplA2 mRNA expression is significantly increased in the late stage of infection only in the LplA1-cKO parasites that are not exposed to anhydrotetracycline

2 entries