6.3.1.20: lipoate-protein ligase
This is an abbreviated version!
For detailed information about lipoate-protein ligase, go to the full flat file.
Word Map on EC 6.3.1.20
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6.3.1.20
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lipoylation
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ligases
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octanoyl-acyl
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lipoate-dependent
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apicoplast
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octanoylation
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2-oxoacids
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lipoyl-amp
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octanoic
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bioorthogonal
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lipoyltransferase
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h-protein
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octanoyltransferase
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13-amino
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biotechnology
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synthesis
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molecular biology
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drug development
- 6.3.1.20
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lipoylation
- ligases
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octanoyl-acyl
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lipoate-dependent
- apicoplast
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octanoylation
- 2-oxoacids
- lipoyl-amp
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octanoic
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bioorthogonal
- lipoyltransferase
- h-protein
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octanoyltransferase
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13-amino
- biotechnology
- synthesis
- molecular biology
- drug development
Reaction
Synonyms
CTD, EC 2.7.7.63, LIP3, LipB, LipL1, lipoate ligase, lipoate ligase like protein, lipoate protein ligase, lipoate protein ligase B, lipoate-bound lipoate ligase 1, lipoate-protein ligase, lipoate-protein ligase A, lipoic acid ligase, lipoic acid ligase A, lipoic acid protein ligase, lipoic acid protein ligase A1, lipoyl ligase, lipoyl-protein ligase A, LPLA, LplA-LplB complex, LplA1, LplA1Ct, Lpla2, LplB, Oryza s. lipoate-protein ligase A, OsLPLA, PfLipL1
ECTree
6.3.1.20 lipoate-protein ligaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.3.1.20 - lipoate-protein ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine
a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
lipoyl-AMP + [GLDH1 protein]-L-lysine
[GLDH1 protein]-N6-(lipoyl)lysine + AMP
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?
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine
a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
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?
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine
a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
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?
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine
a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
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?
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine
a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
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?
ATP + lipoate + apoprotein
AMP + diphosphate + protein N6-(lipoyl)lysine
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protein lipoylation, salvage pathway
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?
ATP + lipoate + apoprotein
AMP + diphosphate + protein N6-(lipoyl)lysine
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protein lipoylation, salvage pathway
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?
lipoic acid + ATP + apoprotein
diphosphate + AMP + N6-(lipoyl)-lysine
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lipoic acid is (R)-5-(1,2-dithiolan-3-yl)pentanoic acid, also called 6,8-dithiooctanoic acid or thioctic acid
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?
lipoic acid + ATP + apoprotein
diphosphate + AMP + N6-(lipoyl)-lysine
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two-step reaction of protein lipoylation at lysine residues with lipoyl-AMP intermediate
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additional information
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LipB protein utilizes lipoyl groups generated via endogenous, LipA mediated biosynthesis and causes the accumulation of aberrantly modified octanoyl-proteins in lipoate-deficient cells
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?
additional information
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LplA potein attaches octanoate to the dehydrogenase and LipA protein then converts the octanoate to lipoate
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?
additional information
?
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LplA's natural protein substrates have a conserved beta-hairpin structure
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?
additional information
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utilization of host-derived lipoyl peptides which is prerequisite for bacterial fitness and intracellular proliferation
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?
additional information
?
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lipoate scavenging by enzymes drives mitochondrial lipoylation, while apicoplast lipoylation relies on biosynthesis
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?
additional information
?
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it is shown that E2 lipoyl domain peptide, LplA and CTD are physically associated. LplA and CTD exist in a ratio 1:1
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?
additional information
?
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it is shown that E2 lipoyl domain peptide, LplA and CTD are physically associated. LplA and CTD exist in a ratio 1:1
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?
additional information
?
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it is shown that E2 lipoyl domain peptide, LplA and CTD are physically associated. LplA and CTD exist in a ratio 1:1
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?
additional information
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LplA has no detectable ligase activity in vitro in the absence of LplB
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?
additional information
?
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LplA has no detectable ligase activity in vitro in the absence of LplB
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?
