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Information on EC 6.3.1.20 - lipoate-protein ligase

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EC Tree
IUBMB Comments
Requires Mg2+. This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid . The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) . Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
lipoic acid ligase, lipoate protein ligase, lpla1, lipoate-protein ligase, lipoate ligase, lipoate-protein ligase a, lipoyl ligase, lipoic acid protein ligase, lipl1, oslpla, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate
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ATP + (R)-lipoate = lipoyl-AMP + diphosphate
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(1a)
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lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP
show the reaction diagram
(1b)
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PATHWAY SOURCE
PATHWAYS
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