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Literature summary for 6.3.1.20 extracted from

  • Guenther, S.; Matuschewski, K.; Mueller, S.
    Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival (2009), PLoS ONE, 4, e5510.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information knockout of Plasmodium falciparum LplA1 failed because the protein is essential for growth of parasite Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast
-
Plasmodium falciparum 20011
-
apicoplast
-
Plasmodium berghei 20011
-
mitochondrion
-
Plasmodium falciparum 5739
-
mitochondrion
-
Plasmodium berghei 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
SDS-PAGE Plasmodium falciparum
45000
-
SDS-PAGE Plasmodium berghei

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
-
-
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-lipoic acid
-
Plasmodium falciparum diphosphate + D-lipoyl-AMP
-
?
ATP + D-lipoic acid
-
Plasmodium berghei diphosphate + D-lipoyl-AMP
-
?

Synonyms

Synonyms Comment Organism
lipoic acid protein ligase
-
Plasmodium falciparum
lipoic acid protein ligase
-
Plasmodium berghei
lipoic acid protein ligase A1
-
Plasmodium falciparum
lipoic acid protein ligase A1
-
Plasmodium berghei
LplA1
-
Plasmodium falciparum
LplA1
-
Plasmodium berghei
Lpla2
-
Plasmodium falciparum
Lpla2
-
Plasmodium berghei

Cofactor

Cofactor Comment Organism Structure
ATP
-
Plasmodium falciparum
ATP
-
Plasmodium berghei

General Information

General Information Comment Organism
malfunction LplA1 knockout cannot be achieved because of the essential function of the gene/protein in asexual parasite growth Plasmodium berghei
metabolism LplA1 plays a critical role for asexual parasite growth in vitro and in vivo. Plasmodium berghei
metabolism LplA1 plays a pivotal role during the development of the erythrocytic stages of the malaria parasite. Plasmodium falciparum
physiological function LplA1 plays a pivotal role during the development of the erythrocytic stages (asexual parasite growth) of Plasmodium falciparum Plasmodium falciparum