6.1.1.4: leucine-tRNA ligase

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For detailed information about leucine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.4

6.1.1.4

aminoacyl-trna

synthetases

aminoacylation

fidelity

leucylation

aarss

mischarged

post-transfer

norvaline

perrault

anticodon

aeolicus

isoacceptors

misactivated

aquifex

ilers

noncognate

valrs

benzoxaborole

isoleucyl-trna

misaminoacylated

hsd17b4

kmsks

metrs

pour

trnaser

clinique

trnaleuuur

valyl-trna

isoleucyl

trna-dependent

pre-transfer

drug development

medicine

Reaction

Synonyms

AaLeuRS, alphabeta-LeuRS, b0642, cytoplasmic LeuRS, EcLeuRS, GlLeuRS, HcleuRS, hs mt LeuRS, JW0637, LARS, LARS1, LARS2, Leucine translase, Leucine--tRNA ligase, Leucyl-transfer ribonucleate synthetase, Leucyl-transfer ribonucleic acid synthetase, Leucyl-transfer RNA synthetase, leucyl-tRNA ligase, leucyl-tRNA syntethase, Leucyl-tRNA synthetase, leucyl-tRNA synthetase 1, leucyl�tRNA synthetase, LeuRS, LeuRS1, LeuRS2, LeuRSTT, leuS, LRS, MmLeuRS, More, mt leucyl-tRNA synthetase, mt-LeuRS, mtLeuRS, PhLeuRS, Synthetase, leucyl-transfer ribonucleate, ycLeuRS

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.4 leucine-tRNA ligase

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Results	in table
11	Activating Compound
58778	AA Sequence
7	Application
1	CAS Registry Number
64	Cloned(Commentary)
62	Cofactor
13	Crystallization (Commentary)
249	Disease/ Diagnostics
1	Expression
65	General Information
7	General Stability
47	IC50 Value
155	Inhibitors
173	kcat/KM [mM/s]
369	KM Value [mM]
48	Localization
71	Metals/Ions
49	Molecular Weight [Da]
78	Natural Substrates/ Products (Substrates)
372	Organism
4	Pathway
118	PDB ID
61	pH Optimum
1	pH Range
3	Posttranslational Modification
348	Protein Variants
65	Purification (Commentary)
10	Reaction
40	Reaction Type
153	Reference
2	Renatured (Commentary)
32	Source Tissue
45	Specific Activity [micromol/min/mg]
8	Storage Stability
265	Substrates and Products (Substrate)
55	Subunits
329	Synonyms
1	Systematic Name
48	Temperature Optimum [°C]
3	Temperature Range [°C]
9	Temperature Stability [°C]
342	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 6.1.1.4 - leucine-tRNA ligase

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A-549 cell

Homo sapiens

LARS1 is over-expressed in lung cancer cell line A549

transmitochondrial, osteosarcoma-derived (143B.TK-) cybrid cell lines from patients

126

274

LARS1 is over-expressed in lung cancer cells compared to control tissue

692229

lung epithelium cell line

LeuRS expression in mammary gland tissue is significantly higher during lactation compared to pregnancy. In pregnancy mammary gland tissue LeuRS showed no difference in the acinar buds and the connective tissue. While in lactating mammary gland tissue, most of LeuRS is expressed in the acinar buds with only a small amount detected in the connective tissue, quantitative real-time PCR expression analysis. the level of LeuRS expression is significantly higher in lactating mammary gland tissue than in pregnancy mammary gland tissue