Reference on EC 6.1.1.4 - leucine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Norcum, M.T.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells
J. Biol. Chem.
264
15043-15051
1989
Mus musculus
Sivaram, P.; Vellekamp, G.; Deutscher, M.P.
A role for lipids in the functional and structural properties of the rat liver aminoacyl-tRNA synthetase complex
J. Biol. Chem.
263
18891-18896
1988
Rattus norvegicus
Wright, H.T.; Nurse, K.C.; Goldstein, D.J.
Naldixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases
Science
213
455-456
1981
Saccharomyces cerevisiae
Carias, J.R.; Mouricout, M.; Quintard, B.; Thomes, J.C.; Julien, R.
Leucyl-tRNA and arginyl-tRNA synthetases of wheat germ. Inactivation and ribosome effects
Eur. J. Biochem.
87
583-590
1978
Triticum aestivum
Hampel, A.; Tritz, R.
Leucine-tRNA ligase complexes
Methods Enzymol.
166
260-265
1988
Cricetulus griseus
Airas, R.K.; Cramer, F.
Pyrophosphate-caused inhibition of the aminoacylation of tRNA by the leucyl-tRNA synthetase from Neurospora crassa
Eur. J. Biochem.
160
291-296
1986
Neurospora crassa
Williamson, R.M.
Membrane association of leucyl-tRNA synthetase during leucine starvation in Escherichia coli
Biochem. Biophys. Res. Commun.
190
794-800
1993
Escherichia coli
Kerjan, P.; Cerini, C.; Semeriva, M.; Mirande, M.
The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals
Biochim. Biophys. Acta
1199
293-297
1994
Bacteria, Drosophila sp. (in: flies), eukaryota, Mammalia
Horner, J.; Champney, W.S.; Samuels, R.
Characteristics of a leucine aminoacyl transfer RNA synthetase from Tritrichomonas augusta
Int. J. Parasitol.
21
275-277
1991
Tritrichomonas augusta
vander Horn, P.B.; Zahler, S.A.
Cloning and nucleotide sequence of the leucyl-tRNA synthetase gene of Bacillus subtilis
J. Bacteriol.
174
3928-3935
1992
Bacillus subtilis
Berg, P.; Bergmann, F.H.; Ofengand, E.J.; Dieckmann, M.
The enzymic synthesis of amino acyl derivatives of ribonucleic acid. The mechanism of leucyl-, valyl-, isoleucyl-, and methionyl ribonucleic acid formation
J. Biol. Chem.
236
1726-1734
1961
Escherichia coli
-
Chirikjian, J.G.; Kanagalingam, K.; Lau, E.; Fresco, J.R.
Purification and properties of leucyl-tRNA synthetase from bakers' yeast
J. Biol. Chem.
248
1074-1079
1973
Saccharomyces cerevisiae
Nathan, I.; Richmond, A.
Leucyl-transfer ribonucleic acid synthetase in scenescing tobacco leaves
Biochem. J.
140
169-173
1974
Nicotiana rustica
Murasugi, A.; Hayashi, H.
Purification and properties of leucyl-tRNA synthetase from Candida utilis
Eur. J. Biochem.
57
169-175
1975
Cyberlindnera jadinii, Cyberlindnera jadinii Torulopsis
Chiu, A.O.S.; Suyama, Y.
The absence of structural relationship between mitochondrial and cytoplasmic leucyl-tRNA synthetases from Tetrahymena pyriformis
Arch. Biochem. Biophys.
171
43-54
1975
Tetrahymena pyriformis
Lin, C.S.; Irwin, R.; Chirikjian, J.G.
Kinetic studies of leucyl transfer RNA synthetase from bakers' yeast. Order of addition of substrates and release of products
J. Biol. Chem.
250
9299-9303
1975
Saccharomyces cerevisiae
Marutzky, R.; Flossdorf, J.; Kula, M.R.
ATP-analogue as substrates for leucyl-TRNA synthetase from Escherichia coli MRE 600
Nucleic Acids Res.
3
2067-2077
1976
Escherichia coli, Escherichia coli MRE 600
Imbault, P.; Colas, B.; Sarantoglou, V.; Boulanger, Y.; Weil, J.H.
Chloroplast leucyl-tRNA synthetase from Euglena gracilis. Purification, kinetic analysis, and structural characterization
Biochemistry
20
5855-5859
1981
Euglena gracilis
Sarantoglou, V.; Imbault, P.; Weil, J.H.
Purification of Euglena gracilis cytoplasmic leucyl tRNA synthetase
Plant Sci. Lett.
22
291-297
1981
Euglena gracilis
-
Colas, B.; Imbault, P.; Sarantoglou, V.; Boulanger, Y.; Weil, J.H.
Chloroplastic and cytoplasmic valyl- and leucyl-tRNA synthetases from Euglena gracilis. Comparative study of their structural properties
Biochim. Biophys. Acta
697
71-77
1982
Euglena gracilis
Souciet, G.; Dietrich, A.; Colas, B.; Razafimahatratra, P.; Weil, J.H.
Purification and properties of chloroplast leucyl-tRNA synthetase from a higher plant. Phaseolus vulgaris
J. Biol. Chem.
257
9598-9604
1982
Phaseolus vulgaris
Imbault, P.; Sarantoglou, V.; Weil, J.H.
Properties of purified chloroplastic and cytoplasmic valyl- and leucyl-tRNA synthetases from Euglena gracilis
Phytochemistry
21
1189-1193
1982
Euglena gracilis
-
Dietrich, A.; Souciet, G.; Colas, B.; Weil, J.H.
Phaseolus vulgaris cytoplasmic leucyl-tRNA synthetase. Purification and comparison of its catalytic, structural, and immunological properties with those of the chloroplastic enzyme
J. Biol. Chem.
258
12386-12393
1983
Phaseolus vulgaris
Mirande, M.; Le Corre, D.; Waller, J.P.
A complex from cultured Chinese hamster ovary cells containing nine aminoacyl-tRNA synthetases. Thermolabile leucyl-tRNA synthetase from the tsH1 mutant cell line is an integral component of this complex
Eur. J. Biochem.
147
281-289
1985
Cricetulus griseus
Cirakoglu, B.; Waller, J.P.
Leucyl-tRNA and lysyl-tRNA synthetases, derived from the high-Mr complex of sheep liver, are hydrophobic proteins
Eur. J. Biochem.
151
101-110
1985
Ovis aries
Kunugi, S.; Uehara-Kunugi, Y.; v.d.Haar, F.; Schischkoff, J.; Freist, W.; Englisch, U.; Cramer, F.
Biochemical comparison of the Neurospora crassa wild type and the temperature-sensitive and leucine-auxotroph mutant leu-5
Eur. J. Biochem.
158
43-49
1986
Neurospora crassa
Airas, R.K.; Schischkoff, J.; Cramer, F.
Biochemical comparison of the Neurospora crassa wild-type and the temperature-sensitive leucine-auxotroph mutant leu-5
Eur. J. Biochem.
158
51-56
1986
Neurospora crassa
Dombou, M.; Nakajima, H.; Kitabatake, S.; Tomita, K.; Imahori, K.
Kinetics of peptide synthesis by the leucyl-tRNA synthetase from Bacillus stearothermophilus
Agric. Biol. Chem.
50
2967-2972
1986
Geobacillus stearothermophilus
-
Tzagoloff, A.; Akai, A.; Kurkulos, M.; Repetto, B.
Homology of yeast mitochondrial leucyl-tRNA synthetase and isoleucyl- and methionyl-tRNA synthetases of Escherichia coli
J. Biol. Chem.
263
850-856
1988
Escherichia coli, Saccharomyces cerevisiae
Herbert, C.J.; Labouesse, M.; Dujardin, G.; Slonimski, P.P.
The NAM2 proteins from S. cerevisiae and S. douglasii are mitochondrial leucyl-tRNA synthetases, and are involved in mRNA splicing
EMBO J.
7
473-483
1988
Escherichia coli, Saccharomyces douglasii
Bergmann, F.H.; Berg, P.; Dieckmann, M.
The Enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl-, and methionyl ribonucleic acid synthetases from Escherichia coli
J. Biol. Chem.
236
1735-1740
1961
Escherichia coli
-
Yaremchuk, A.; Cusack, S.; Gudzera, O.; Grotli, M.; Tukalo, M.
Crystallization and preliminary crystallographic analysis of Thermus thermophilus leucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue
Acta Crystallogr. Sect. D
56
667-669
2000
Thermus thermophilus
Gouda, M.; Yokogawa, T.; Nishikawa, K.
The beta-subunit of Aquifex aeolicus leucyltRNA synthetase is responsible for cognate tRNA recognition
Biochem. Biophys. Res. Commun.
297
950-955
2002
Aquifex aeolicus
Li, T.; Guo, N.; Xia, X.; Wang, E.D.; Wang, Y.L.
The peptide bond between E292-A293 of Escherichia coli leucyl-tRNA synthetase is essential for its activity
Biochemistry
38
13063-13069
1999
Escherichia coli
Chen, J.F.; Guo, N.N.; Li, T.; Wang, E.D.; Wang, Y.L.
CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function
Biochemistry
39
6726-6731
2000
Escherichia coli
Chen, J.F.; Li, T.; Wang, E.D.; Wang, Y.L.
Effect of alanine-293 replacement on the activity, ATP binding, and editing of Escherichia coli leucyl-tRNA synthetase
Biochemistry
40
1144-1149
2001
Escherichia coli
Tang, Y.; Tirrell, D.A.
Attenuation of the editing activity of the Escherichia coli leucyl-tRNA synthetase allows incorporation of novel amino acids into proteins in vivo
Biochemistry
41
10635-10645
2002
Escherichia coli
Zhao, M.W.; Hao, R.; Chen, J.F.; Martin, F.; Eriani, G.; Wang, E.D.
Enzymes assembled from Aquifex aeolicus and Escherichia coli leucyl-tRNA synthetases
Biochemistry
42
7694-7700
2003
Aquifex aeolicus, Escherichia coli
Bullard, J.M.; Cai, Y.C.; Spremulli, L.L.
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
Biochim. Biophys. Acta
1490
245-258
2000
Homo sapiens (Q15031), Homo sapiens
Gouda, M.; Yokogawa, T.; Asahara, H.; Nishikawa, K.
Leucyl-tRNA synthetase from the extreme thermophile Aquifex aeolicus has a heterodimeric quaternary structure
FEBS Lett.
518
139-143
2002
Aquifex aeolicus
Nathanson, L.; Deutscher, M.P.
Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex
J. Biol. Chem.
275
31559-31562
2000
Cricetulus griseus
Xu, M.G.; Chen, J.F.; Martin, F.; Zhao, M.W.; Eriani, G.; Wang, E.D.
Leucyl-tRNA synthetase consisting of two subunits from hyperthermophilic bacteria Aquifex aeolicus
J. Biol. Chem.
277
41590-41596
2002
Aquifex aeolicus
Soma, A.; Uchiyama, K.; Sakamoto, T.; Maeda, M.; Himeno, H.
Unique recognition style of tRNA(Leu) by Haloferax volcanii leucyl-tRNA synthetase
J. Mol. Biol.
293
1029-1038
1999
Haloferax volcanii
Du, X.; Wang, E.D.
E292 is important for the aminoacylation activity of Escherichia coli leucyl-tRNA synthetase
J. Protein Chem.
22
71-76
2003
Escherichia coli
Lincecum, T.L., Jr.; Tukalo, M.; Yaremchuk, A.; Mursinna, R.S.; Williams, A.M.; Sproat, B.S.; Van Den Eynde, W.; Link, A.; Van Calenbergh, S.; Grotli, M.; Martinis, S.A.; Cusack, S.
Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase
Mol. Cell
11
951-963
2003
Saccharomyces cerevisiae, Escherichia coli, Thermus thermophilus (Q72GM3)
Chen, J.; Li, Y.; Wang, E.; Wang, Y.
High-level expression and single-step purification of leucyl-tRNA synthetase from Escherichia coli
Protein Expr. Purif.
15
115-120
1999
Escherichia coli
Yao, Y.N.; Wang, L.; Wu, X.F.; Wang, E.D.
Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli
Protein Expr. Purif.
30
112-116
2003
Homo sapiens
Xu, M.G.; Li, J.; Du, X.; Wang, E.D.
Groups on the side chain of T252 in Escherichia coli leucyl-tRNA synthetase are important for discrimination of amino acids and cell viability
Biochem. Biophys. Res. Commun.
318
11-16
2004
Escherichia coli
Liu, Y.; Liao, J.; Zhu, B.; Wang, E.; Ding, J.
Crystal structures of the editing domain of E. coli leucyl-tRNA synthetase and its complexes with methionine and isoleucine reveal a lock-and-key mechanism for amino acid discrimination
Biochem. J.
394
399-407
2006
Escherichia coli (P07813), Escherichia coli
Mursinna, R.S.; Lee, K.W.; Briggs, J.M.; Martinis, S.A.
Molecular dissection of a critical specificity determinant within the amino acid editing domain of leucyl-tRNA synthetase
Biochemistry
43
155-165
2004
Escherichia coli
Zhai, Y.; Martinis, S.A.
Two conserved threonines collaborate in the Escherichia coli leucyl-tRNA synthetase amino acid editing mechanism
Biochemistry
44
15437-15443
2005
Escherichia coli
Lue, S.W.; Kelley, S.O.
An aminoacyl-tRNA synthetase with a defunct editing site
Biochemistry
44
3010-3016
2005
Escherichia coli, Homo sapiens
Zhao, M.W.; Zhu, B.; Hao, R.; Xu, M.G.; Eriani, G.; Wang, E.D.
Leucyl-tRNA synthetase from the ancestral bacterium Aquifex aeolicus contains relics of synthetase evolution
EMBO J.
24
1430-1439
2005
Aquifex aeolicus
Xu, M.G.; Zhao, M.W.; Wang, E.D.
Leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus recognizes minihelices
J. Biol. Chem.
279
32151-32158
2004
Aquifex aeolicus
Ling, C.; Yao, Y.N.; Zheng, Y.G.; Wei, H.; Wang, L.; Wu, X.F.; Wang, E.D.
The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex
J. Biol. Chem.
280
34755-34763
2005
Homo sapiens
Sohm, B.; Sissler, M.; Park, H.; King, M.P.; Florentz, C.
Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase
J. Mol. Biol.
339
17-29
2004
Homo sapiens
Fukunaga, R.; Yokoyama, S.
Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation
J. Mol. Biol.
346
57-71
2005
Pyrococcus horikoshii
Tukalo, M.; Yaremchuk, A.; Fukunaga, R.; Yokoyama, S.; Cusack, S.
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation
Nat. Struct. Mol. Biol.
12
923-930
2005
Thermus thermophilus
Zheng, Y.G.; Wei, H.; Ling, C.; Martin, F.; Eriani, G.; Wang, E.D.
Two distinct domains of the beta subunit of Aquifex aeolicus leucyl-tRNA synthetase are involved in tRNA binding as revealed by a three-hybrid selection
Nucleic Acids Res.
32
3294-3303
2004
Aquifex aeolicus
Ling, C.; Zheng, Y.G.; Wang, E.D.
High-level expression and single-step purification of leucyl-tRNA synthetase from Aquifex aeolicus
Protein Expr. Purif.
36
146-149
2004
Aquifex aeolicus
Olieric, N.; Bey, G.; Nierengarten, H.; Wang, E.D.; Moras, D.; Eriani, G.; Cavarelli, J.
Expression, purification, and characterization of a new heterotetramer structure of leucyl-tRNA synthetase from Aquifex aeolicus in Escherichia coli
Protein Expr. Purif.
47
1-9
2006
Aquifex aeolicus
Lee, K.W.; Briggs, J.M.
Molecular modeling study of the editing active site of Escherichia coli leucyl-tRNA synthetase: two amino acid binding sites in the editing domain
Proteins
54
693-704
2004
Escherichia coli
Ma, J.J.; Zhao, M.W.; Wang, E.D.
Split leucine-specific domain of leucyl-tRNA synthetase from the hyperthermophilic bacterium Aquifex aeolicus
Biochemistry
45
14809-14816
2006
Aquifex aeolicus
Zhai, Y.; Nawaz, M.H.; Lee, K.W.; Kirkbride, E.; Briggs, J.M.; Martinis, S.A.
Modulation of substrate specificity within the amino acid editing site of leucyl-tRNA synthetase
Biochemistry
46
3331-3337
2007
Escherichia coli
Lue, S.W.; Kelley, S.O.
A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation
Biochemistry
46
4466-4472
2007
Escherichia coli, Homo sapiens
Fukunaga, R.; Yokoyama, S.
The C-terminal domain of the archaeal leucyl-tRNA synthetase prevents misediting of isoleucyl-tRNA(Ile)
Biochemistry
46
4985-4996
2007
Pyrococcus horikoshii
Vu, M.T.; Martinis, S.A.
A unique insert of leucyl-tRNA synthetase is required for aminoacylation and not amino acid editing
Biochemistry
46
5170-5176
2007
Escherichia coli
Betha, A.K.; Williams, A.M.; Martinis, S.A.
Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity
Biochemistry
46
6258-6267
2007
Escherichia coli
Viezeliene, D.; Rodovicius, H.; Ivanov, L.
Effect of aluminum ions on the activities of tRNALeu and leucyl-tRNA synthetase in mouse liver in vivo and in vitro
Biologija (Vilnius)
4
28-30
2006
Mus musculus
-
Hsu, J.L.; Rho, S.B.; Vannella, K.M.; Martinis, S.A.
Functional divergence of a unique C-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles
J. Biol. Chem.
281
23075-23082
2006
Saccharomyces cerevisiae, Escherichia coli
Karkhanis, V.A.; Boniecki, M.T.; Poruri, K.; Martinis, S.A.
A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria
J. Biol. Chem.
281
33217-33225
2006
Saccharomyces cerevisiae
Praetorius-Ibba, M.; Hausmann, C.D.; Paras, M.; Rogers, T.E.; Ibba, M.
Functional association between three archaeal aminoacyl-tRNA synthetases
J. Biol. Chem.
282
3680-3687
2007
Methanothermobacter thermautotrophicus
Nawaz, M.H.; Pang, Y.L.; Martinis, S.A.
Molecular and functional dissection of a putative RNA-binding region in yeast mitochondrial leucyl-tRNA synthetase
J. Mol. Biol.
367
384-394
2007
Saccharomyces cerevisiae
Zhu, B.; Zhao, M.W.; Eriani, G.; Wang, E.D.
A present-day aminoacyl-tRNA synthetase with ancestral editing properties
RNA
13
15-21
2007
Aquifex aeolicus
Mascarenhas, A.P.; Martinis, S.A.
Functional segregation of a predicted hinge site within the beta-strand linkers of Escherichia coli leucyl-tRNA synthetase
Biochemistry
47
4808-4816
2008
Escherichia coli
Shin, S.H.; Kim, H.S.; Jung, S.H.; Xu, H.D.; Jeong, Y.B.; Chung, Y.J.
Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis
Exp. Mol. Med.
40
229-236
2008
Homo sapiens
Yao, P.; Zhou, X.L.; He, R.; Xue, M.Q.; Zheng, Y.G.; Wang, Y.F.; Wang, E.D.
Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain
J. Biol. Chem.
283
22591-22600
2008
Homo sapiens, Saccharomyces cerevisiae (P26637), Saccharomyces cerevisiae
Wang, X.; Fonseca, B.D.; Tang, H.; Liu, R.; Elia, A.; Clemens, M.J.; Bommer, U.A.; Proud, C.G.
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling
J. Biol. Chem.
283
30482-30492
2008
Cricetulus griseus
Zhou, X.L.; Zhu, B.; Wang, E.D.
The CP2 domain of leucyl-tRNA synthetase is crucial for amino acid activation and post-transfer editing
J. Biol. Chem.
283
36608-36616
2008
Giardia intestinalis
Hsu, J.L.; Martinis, S.A.
A flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in Leucyl-tRNA synthetases
J. Mol. Biol.
376
482-491
2008
Saccharomyces cerevisiae, Escherichia coli
Staneviciene, I.; Sadauskiene, I.; Lesauskaite, V.; Ivanoviene, L.; Kasauskas, A.; Ivanov, L.
Subacute effects of cadmium and zinc ions on protein synthesis and cell death in mouse liver
Medicina (Kaunas)
44
131-138
2008
Mus musculus
Yao, P.; Zhu, B.; Jaeger, S.; Eriani, G.; Wang, E.D.
Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps
Nucleic Acids Res.
36
2728-2738
2008
Aquifex aeolicus
Park, H.; Davidson, E.; King, M.P.
Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
RNA
14
2407-2416
2008
Homo sapiens
Zhou, X.L.; Wang, E.D.
Two tyrosine residues outside the editing active site in Giardia lamblia leucyl-tRNA synthetase are essential for the post-transfer editing
Biochem. Biophys. Res. Commun.
386
510-515
2009
Giardia intestinalis
Zhou, X.L.; Yao, P.; Ruan, L.L.; Zhu, B.; Luo, J.; Qu, L.H.; Wang, E.D.
A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase
Biochemistry
48
1340-1347
2009
Giardia intestinalis
Pang, Y.L.; Martinis, S.A.
A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase
Biochemistry
48
8958-8964
2009
Homo sapiens (Q9P2J5), Homo sapiens
Tang, Y.; Wang, P.; Van Deventer, J.; Link, A.; Tirrell, D.
Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase
ChemBioChem
10
2188-2190
2009
Escherichia coli
Mascarenhas, A.P.; Martinis, S.A.
A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase
FEBS Lett.
583
3443-3447
2009
Escherichia coli
Hagiwara, Y.; Nureki, O.; Tateno, M.
Structural modelling of the complex of leucyl-tRNA synthetase and mis-aminoacylated tRNALeu
FEBS Lett.
583
825-830
2009
Thermus thermophilus (Q72GM3)
Boniecki, M.T.; Rho, S.B.; Tukalo, M.; Hsu, J.L.; Romero, E.P.; Martinis, S.A.
Leucyl-tRNA synthetase-dependent and -independent activation of a group I intron
J. Biol. Chem.
284
26243-26250
2009
Saccharomyces cerevisiae
Zhu, B.; Yao, P.; Tan, M.; Eriani, G.; Wang, E.
tRNA-independent pretransfer editing by class I leucyl-tRNA synthetase
J. Biol. Chem.
284
3418-3424
2009
Aquifex aeolicus
Tan, M.; Zhu, B.; Zhou, X.L.; He, R.; Chen, X.; Eriani, G.; Wang, E.D.
tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase
J. Biol. Chem.
285
3235-3244
2010
Aquifex aeolicus, Escherichia coli
Seiradake, E.; Mao, W.; Hernandez, V.; Baker, S.J.; Plattner, J.J.; Alley, M.R.; Cusack, S.
Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles
J. Mol. Biol.
390
196-207
2009
Candida albicans, Homo sapiens
Li, R.; Guan, M.X.
Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
Mol. Cell. Biol.
30
2147-2154
2010
Homo sapiens
Zhou, X.L.; Wang, M.; Tan, M.; Huang, Q.; Eriani, G.; Wang, E.D.
Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases
Biochem. J.
429
505-513
2010
Giardia intestinalis, Pyrococcus horikoshii
Zhou, X.L.; Tan, M.; Wang, M.; Chen, X.; Wang, E.D.
Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690
Biochem. J.
430
325-333
2010
Giardia intestinalis
Montanari, A.; De Luca, C.; Frontali, L.; Francisci, S.
Aminoacyl-tRNA synthetases are multivalent suppressors of defects due to human equivalent mutations in yeast mt tRNA genes
Biochim. Biophys. Acta
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2010
Homo sapiens
Gudzera, O.; Yaremchuk, A.; Tukalo, M.
Functional role of C-terminal domain of Thermus thermophilus leucyl-tRNA synthetase
Biopolym. Cell
26
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2010
Thermus thermophilus
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Hagiwara, Y.; Field, M.J.; Nureki, O.; Tateno, M.
Editing mechanism of aminoacyl-tRNA synthetases operates by a hybrid ribozyme/protein catalyst
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Thermus thermophilus
Ding, D.; Meng, Q.; Gao, G.; Zhao, Y.; Wang, Q.; Nare, B.; Jacobs, R.; Rock, F.; Alley, M.R.; Plattner, J.J.; Chen, G.; Li, D.; Zhou, H.
Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents
J. Med. Chem.
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Trypanosoma brucei
Chen, X.; Ma, J.J.; Tan, M.; Yao, P.; Hu, Q.H.; Eriani, G.; Wang, E.D.
Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
Nucleic Acids Res.
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Homo sapiens
Fukunaga, R.; Yokoyama, S.
Crystallization and preliminary X-ray crystallographic study of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii
Acta Crystallogr. Sect. D
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Pyrococcus horikoshii
Fukunaga, R.; Ishitani, R.; Nureki, O.; Yokoyama, S.
Crystallization of leucyl-tRNA synthetase complexed with tRNALeu from the archaeon Pyrococcus horikoshii
Acta Crystallogr. Sect. F
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2004
Pyrococcus horikoshii
Tan, M.; Zhu, B.; Liu, R.J.; Chen, X.; Zhou, X.L.; Wang, E.D.
Interdomain communication modulates the tRNA-dependent pre-transfer editing of leucyl-tRNA synthetase
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Escherichia coli (P07813)
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Leucyl-tRNA synthetase: double duty in amino acid sensing
Cell Res.
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Saccharomyces cerevisiae, Homo sapiens
Han, J.M.; Jeong, S.J.; Park, M.C.; Kim, G.; Kwon, N.H.; Kim, H.K.; Ha, S.H.; Ryu, S.H.; Kim, S.
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
Cell
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Homo sapiens
Perli, E.; Giordano, C.; Pisano, A.; Montanari, A.; Campese, A.F.; Reyes, A.; Ghezzi, D.; Nasca, A.; Tuppen, H.A.; Orlandi, M.; Di Micco, P.; Poser, E.; Taylor, R.W.; Colotti, G.; Francisci, S.; Morea, V.; Frontali, L.; Zeviani, M.; dAmati, G.
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells
EMBO Mol. Med.
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2014
Homo sapiens
Hu, Q.H.; Huang, Q.; Wang, E.D.
Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing
Nucleic Acids Res.
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2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Yan, W.; Tan, M.; Eriani, G.; Wang, E.D.
Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase
Nucleic Acids Res.
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Mesomycoplasma mobile
Fang, Z.P.; Wang, M.; Ruan, Z.R.; Tan, M.; Liu, R.J.; Zhou, M.; Zhou, X.L.; Wang, E.D.
Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNALeu in the archaeal mode
Nucleic Acids Res.
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Natrialba magadii, Natrialba magadii ATCC 43099
Li, L.; Palencia, A.; Lukk, T.; Li, Z.; Luthey-Schulten, Z.A.; Cusack, S.; Martinis, S.A.; Boniecki, M.T.
Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens
Proc. Natl. Acad. Sci. USA
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2013
Mycoplasmopsis synoviae, Mesomycoplasma mobile
Choi, H.; Son, J.B.; Kang, J.; Kwon, J.; Kim, J.H.; Jung, M.; Kim, S.K.; Kim, S.; Mun, J.Y.
Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane
Biochem. Biophys. Res. Commun.
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Homo sapiens
Yoon, M.S.; Son, K.; Arauz, E.; Han, J.M.; Kim, S.; Chen, J.
Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling
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Homo sapiens (Q9P2J5)
Kim, C.; Jung, J.; Tung, T.T.; Park, S.B.
beta-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase
Chem. Sci.
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Homo sapiens (Q9P2J5)
Perli, E.; Giordano, C.; Pisano, A.; Montanari, A.; Campese, A.F.; Reyes, A.; Ghezzi, D.; Nasca, A.; Tuppen, H.A.; Orlandi, M.; Di Micco, P.; Poser, E.; Taylor, R.W.; Colotti, G.; Francisci, S.; Morea, V.; Frontali, L.; Zeviani, M.; dAmati, G.
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells
EMBO Mol. Med.
6
169-182
2014
Homo sapiens (Q15031), Homo sapiens
Sato, Y.; Sato, Y.; Suzuki, R.; Obeng, K.; Yoshizawa, F.
Leucyl-tRNA synthetase is required for the myogenic differentiation of C2C12 myoblasts, but not for hypertrophy or metabolic alteration of myotubes
Exp. Cell Res.
364
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Mus musculus (Q8VDC0), Mus musculus
Giordano, C.; Morea, V.; Perli, E.; dAmati, G.
The phenotypic expression of mitochondrial tRNA-mutations can be modulated by either mitochondrial leucyl-tRNA synthetase or the C-terminal domain thereof
Front. Genet.
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Homo sapiens (Q15031), Homo sapiens
Wang, L.; Lin, Y.; Bian, Y.; Liu, L.; Shao, L.; Lin, L.; Qu, B.; Zhao, F.; Gao, X.; Li, Q.
Leucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cells
Int. J. Mol. Sci.
15
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Bos taurus (A6QLR2), Bos taurus
Yan, W.; Ye, Q.; Tan, M.; Chen, X.; Eriani, G.; Wang, E.D.
Modulation of aminoacylation and editing properties of leucyl-tRNA synthetase by a conserved structural module
J. Biol. Chem.
290
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2015
Pyrococcus horikoshii (O58698), Aquifex aeolicus (O66680 AND O67646), Escherichia coli (P07813), Escherichia coli, Mesomycoplasma mobile (Q6KHA5), Homo sapiens (Q9P2J5), Mesomycoplasma mobile ATCC 43663 / 163K / NCTC 11711 (Q6KHA5), Pyrococcus horikoshii ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 (O58698)
Gudzera, O.I.; Golub, A.G.; Bdzhola, V.G.; Volynets, G.P.; Kovalenko, O.P.; Boyarshin, K.S.; Yaremchuk, A.D.; Protopopov, M.V.; Yarmoluk, S.M.; Tukalo, M.A.
Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one
J. Enzyme Inhib. Med. Chem.
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Mycobacterium tuberculosis (P9WFV1), Mycobacterium tuberculosis, Homo sapiens (Q9P2J5), Homo sapiens, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WFV1)
Kumar, M.; Kumar, S.A.; Dimkovikj, A.; Baykal, L.N.; Banton, M.J.; Outlaw, M.M.; Polivka, K.E.; Hellmann-Whitaker, R.A.
Zinc is the molecular switch that controls the catalytic cycle of bacterial leucyl-tRNA synthetase
J. Inorg. Biochem.
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Escherichia coli (P07813), Escherichia coli
Dulic, M.; Cvetesic, N.; Zivkovic, I.; Palencia, A.; Cusack, S.; Bertosa, B.; Gruic-Sovulj, I.
Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase
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Escherichia coli (P07813), Escherichia coli
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