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6.1.1.4: leucine-tRNA ligase

This is an abbreviated version!
For detailed information about leucine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.4

Reaction

ATP
+
L-leucine
 +
tRNALeu
=
AMP
 +
diphosphate
 +
L-leucyl-tRNALeu

Synonyms

AaLeuRS, alphabeta-LeuRS, b0642, cytoplasmic LeuRS, EcLeuRS, GlLeuRS, HcleuRS, hs mt LeuRS, JW0637, LARS, LARS1, LARS2, Leucine translase, Leucine--tRNA ligase, Leucyl-transfer ribonucleate synthetase, Leucyl-transfer ribonucleic acid synthetase, Leucyl-transfer RNA synthetase, leucyl-tRNA ligase, leucyl-tRNA syntethase, Leucyl-tRNA synthetase, leucyl-tRNA synthetase 1, leucyl—tRNA synthetase, LeuRS, LeuRS1, LeuRS2, LeuRSTT, leuS, LRS, MmLeuRS, More, mt leucyl-tRNA synthetase, mt-LeuRS, mtLeuRS, PhLeuRS, Synthetase, leucyl-transfer ribonucleate, ycLeuRS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.4 leucine-tRNA ligase

IC50 Value

IC50 Value on EC 6.1.1.4 - leucine-tRNA ligase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.209
(2E)-3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)-1-phenylprop-2-en-1-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.412
(2E)-3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)-1-phenylprop-2-en-1-one
Trypanosoma brucei
-
pH 7.8, 37°C
1
(E)-[3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl)]acrylic acid ethyl ester
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.0323
1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl cyclohexylcarbamate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0431
1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl phenylcarbamate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0676
1-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]-4-methylpentan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0272
1-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]butan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0308
1-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]pentan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0221
2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.0309
2,1-benzoxaborole-1,6(3H)-diol
Trypanosoma brucei
-
pH 7.8, 37°C
0.0025
2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]pentan-3-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
2-[3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]propyl]-1H-isoindole-1,3(2H)-dione
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.005
3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]-3-methylbutan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0045
3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]-4-methylpentan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0038
3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]butan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0029
3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]heptan-4-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0314
3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]hexan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0035
3-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]pentan-2-one
Trypanosoma brucei
-
pH 7.8, 37°C
0.0713
6-(2,2-dimethoxyethoxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
6-(2-methoxyethoxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.688
6-(3-hydroxypropyl)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.0306
6-(benzyloxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
6-(cyclohexylmethoxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.0158
6-(propan-2-yloxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
6-(pyridin-2-ylmethoxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.063
6-(quinolin-2-yloxy)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.0543
6-butoxy-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.013
6-ethoxy-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.0309
6-propoxy-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.0256
6-[(2-fluorobenzyl)oxy]-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
6-[(3-hydroxypentan-2-yl)oxy]-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.541
7-(3-hydroxypropyl)-2,1-benzoxaborol-1(3H)-ol
Trypanosoma brucei
-
pH 7.8, 37°C
0.578
ethyl (2E)-3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)prop-2-enoate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0021
ethyl 2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]-2-methylpropanoate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0016
ethyl 2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]butanoate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0028
ethyl 2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]propanoate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0167
ethyl 3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)propanoate
Trypanosoma brucei
-
pH 7.8, 37°C
1
ethyl 3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoate
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.0417
ethyl [(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy](phenyl)acetate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0035
ethyl [(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0036
methyl [(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetate
Trypanosoma brucei
-
pH 7.8, 37°C
0.0777
N-ethyl-2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetamide
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
N-tert-butyl-2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetamide
Trypanosoma brucei
-
above, I114pH 7.8, 37°C
0.0074
tert-butyl [(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetate
Trypanosoma brucei
-
pH 7.8, 37°C
0.1
tert-butyl [2-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]ethyl]carbamate
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.1
[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetaldehyde
Trypanosoma brucei
-
above, pH 7.8, 37°C
0.1
[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-6-yl)oxy]acetic acid
Trypanosoma brucei
-
above, pH 7.8, 37°C