5.3.3.12: L-dopachrome isomerase
This is an abbreviated version!
For detailed information about L-dopachrome isomerase, go to the full flat file.
Word Map on EC 5.3.3.12
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5.3.3.12
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tyrosinase
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melanin
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melanoma
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tyrosinase-related
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melanocyte
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melanogenesis
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melanogenic
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microphthalmia-associated
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melanosomes
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hyperpigmentation
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protein-2
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anti-melanogenic
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whitening
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melanogenesis-related
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microphthalmia
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pigmentary
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dhica
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melanoma-associated
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amelanotic
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trp1
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melanoblast
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skin-whitening
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melanocyte-specific
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5,6-dihydroxyindole
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depigment
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pheomelanin
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vitiligo
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depigmentation
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5,6-dihydroxyindole-2-carboxylic
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crest-derived
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chemokine-like
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tautomerization
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melanin-producing
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cloudman
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premelanosome
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arbutin
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medicine
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drug development
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pmel17
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alpha-msh
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alpha-melanocyte
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anti-melanogenesis
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mart-1
- 5.3.3.12
- tyrosinase
- melanin
- melanoma
-
tyrosinase-related
- melanocyte
-
melanogenesis
-
melanogenic
-
microphthalmia-associated
- melanosomes
- hyperpigmentation
- protein-2
-
anti-melanogenic
-
whitening
-
melanogenesis-related
- microphthalmia
-
pigmentary
-
dhica
-
melanoma-associated
-
amelanotic
- trp1
-
melanoblast
-
skin-whitening
-
melanocyte-specific
- 5,6-dihydroxyindole
-
depigment
-
pheomelanin
- vitiligo
-
depigmentation
-
5,6-dihydroxyindole-2-carboxylic
-
crest-derived
-
chemokine-like
-
tautomerization
-
melanin-producing
-
cloudman
-
premelanosome
- arbutin
- medicine
- drug development
- pmel17
- alpha-msh
-
alpha-melanocyte
-
anti-melanogenesis
-
mart-1
Reaction
Synonyms
brown (b) locus protein, D-dopachrome isomerase, D-dopachrome tautomerase, D-DT, DCF, DCT, DDT, dopachrome conversion factor, dopachrome delta-isomerase, dopachrome DELTA7-DELTA2-isomerase, dopachrome oxidoreductase, dopachrome tautomerase, dopachrome-rearranging enzyme, isomerase, dopachrome DELTA-, L-dopachchrome-methyl ester tautomerase, macrophage inhibitory factor, Macrophage migration inhibitory factor, macrophage migration-inhibitory factor, MIF, Mif-2, SLATY locus protein, TRP-2, TRP2, tyrosine-related protein 2
ECTree
5.3.3.12 L-dopachrome isomeraseAdvanced search results
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Source Tissue on EC 5.3.3.12 - L-dopachrome isomerase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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peripheral blood mononuclear cells, expression in wild-type but no enzyme expression in vitiligo patients, overview
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blocking endogenous enzyme by RNAi decreases proliferation of embryoic cortical neural progenitor cells
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overexpression of enzyme in subventricular zone cells of adult mice significantly increases the number of cells, whereas silencing Dct enzyme by RNAi decreases the cell number
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enzyme is expressed in all layers of the dorsal telencephalon in E10.5
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at E15.5 and E17.5, enzyme expression is primarily localized to the ventricular zone
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measuring of the spatial and temporal pattern of enzyme expression in vivo during neocortical neurogenesis. Enzyme is expressed in all layers of the dorsal telencephalon in E10.5. At E15.5 and E17.5, expression is primarily localized to the ventricular zone. Blocking endogenous enzyme by RNAi decreases proliferation of embryoic cortical neural progenitor cells. In adult brain, strong expression is observed in rostral migratory stream and septum. Overexpression of enzyme in subventricular zone cells of adult mice significantly increases the number of cells, whereas silencing Dct enzyme by RNAi decreases the cell number
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levels of DCT are elevated in melanoma cell lines that are especially resistant to chemotherapy and radiation
