5.3.3.12: L-dopachrome isomerase

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For detailed information about L-dopachrome isomerase, go to the full flat file.

Word Map on EC 5.3.3.12

5.3.3.12

tyrosinase

melanin

melanoma

tyrosinase-related

melanocyte

melanogenesis

melanogenic

microphthalmia-associated

melanosomes

hyperpigmentation

protein-2

anti-melanogenic

whitening

melanogenesis-related

microphthalmia

pigmentary

dhica

melanoma-associated

amelanotic

trp1

melanoblast

skin-whitening

melanocyte-specific

5,6-dihydroxyindole

depigment

pheomelanin

vitiligo

depigmentation

5,6-dihydroxyindole-2-carboxylic

crest-derived

chemokine-like

tautomerization

melanin-producing

cloudman

premelanosome

arbutin

medicine

drug development

pmel17

alpha-msh

alpha-melanocyte

anti-melanogenesis

mart-1

Reaction

Synonyms

brown (b) locus protein, D-dopachrome isomerase, D-dopachrome tautomerase, D-DT, DCF, DCT, DDT, dopachrome conversion factor, dopachrome delta-isomerase, dopachrome DELTA7-DELTA2-isomerase, dopachrome oxidoreductase, dopachrome tautomerase, dopachrome-rearranging enzyme, isomerase, dopachrome DELTA-, L-dopachchrome-methyl ester tautomerase, macrophage inhibitory factor, Macrophage migration inhibitory factor, macrophage migration-inhibitory factor, MIF, Mif-2, SLATY locus protein, TRP-2, TRP2, tyrosine-related protein 2

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.3 Transposing C=C bonds

5.3.3.12 L-dopachrome isomerase

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Results	in table
4	Activating Compound
36	AA Sequence
9	Application
1	CAS Registry Number
9	Cloned(Commentary)
924	Disease/ Diagnostics
5	Expression
23	General Information
7	IC50 Value
32	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
8	Localization
7	Metals/Ions
3	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
192	Organism
3	Pathway
268	PDB ID
2	pH Optimum
1	pH Range
2	Posttranslational Modification
7	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
53	Reference
75	Source Tissue
1	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
5	Subunits
67	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

IC50 Value

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IC50 Value on EC 5.3.3.12 - L-dopachrome isomerase

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0.0031

2-piperidinoethyl isothiocyanate

Homo sapiens

702357

0.0037

allyl isothiocyamate

Homo sapiens

702357

0.0008

Benzyl isothiocyanate

Homo sapiens

702357

0.0111

ethyl isothiocyanate

Homo sapiens

702357

0.0014

methallyl isothiocyanate

Homo sapiens

702357

0.005 - 0.006

phenethylisothiocyanate

Homo sapiens

702139

0.001 - 0.002

sulforaphane

Homo sapiens

702139