5.3.3.12: L-dopachrome isomerase
This is an abbreviated version!
For detailed information about L-dopachrome isomerase, go to the full flat file.
Word Map on EC 5.3.3.12
-
5.3.3.12
-
tyrosinase
-
melanin
-
melanoma
-
tyrosinase-related
-
melanocyte
-
melanogenesis
-
melanogenic
-
microphthalmia-associated
-
melanosomes
-
hyperpigmentation
-
protein-2
-
anti-melanogenic
-
whitening
-
melanogenesis-related
-
microphthalmia
-
pigmentary
-
dhica
-
melanoma-associated
-
amelanotic
-
trp1
-
melanoblast
-
skin-whitening
-
melanocyte-specific
-
5,6-dihydroxyindole
-
depigment
-
pheomelanin
-
vitiligo
-
depigmentation
-
5,6-dihydroxyindole-2-carboxylic
-
crest-derived
-
chemokine-like
-
tautomerization
-
melanin-producing
-
cloudman
-
premelanosome
-
arbutin
-
medicine
-
drug development
-
pmel17
-
alpha-msh
-
alpha-melanocyte
-
anti-melanogenesis
-
mart-1
- 5.3.3.12
- tyrosinase
- melanin
- melanoma
-
tyrosinase-related
- melanocyte
-
melanogenesis
-
melanogenic
-
microphthalmia-associated
- melanosomes
- hyperpigmentation
- protein-2
-
anti-melanogenic
-
whitening
-
melanogenesis-related
- microphthalmia
-
pigmentary
-
dhica
-
melanoma-associated
-
amelanotic
- trp1
-
melanoblast
-
skin-whitening
-
melanocyte-specific
- 5,6-dihydroxyindole
-
depigment
-
pheomelanin
- vitiligo
-
depigmentation
-
5,6-dihydroxyindole-2-carboxylic
-
crest-derived
-
chemokine-like
-
tautomerization
-
melanin-producing
-
cloudman
-
premelanosome
- arbutin
- medicine
- drug development
- pmel17
- alpha-msh
-
alpha-melanocyte
-
anti-melanogenesis
-
mart-1
Reaction
Synonyms
brown (b) locus protein, D-dopachrome isomerase, D-dopachrome tautomerase, D-DT, DCF, DCT, DDT, dopachrome conversion factor, dopachrome delta-isomerase, dopachrome DELTA7-DELTA2-isomerase, dopachrome oxidoreductase, dopachrome tautomerase, dopachrome-rearranging enzyme, isomerase, dopachrome DELTA-, L-dopachchrome-methyl ester tautomerase, macrophage inhibitory factor, Macrophage migration inhibitory factor, macrophage migration-inhibitory factor, MIF, Mif-2, SLATY locus protein, TRP-2, TRP2, tyrosine-related protein 2
ECTree
Advanced search results
Engineering
Engineering on EC 5.3.3.12 - L-dopachrome isomerase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
G486R
-
slaty light mutation, 28fold reduction in enzyme activity, sliding of transmembrane domain towards N-terminus of protein thus interfering with the active site. Increase in pheomelanin and reduction in eumelanin produced by melanocytes in culture
P1G
-
generation of knockout mice in which the endogenous mif gene is replaced by one encoding a tautomerase-null, Pro1-Gly1 MIF protein, i.e. P1G-MIF, which is P1G-MIF is catalytically completely inactive, but maintains significant, albeit reduced, binding to its cell surface receptor CD74 and to the intracellular binding protein JAB1/CSN5. Mutant mice show a phenotype in assays of growth control and tumor induction that is intermediate between those of the wild type mif+/+ and complete MIF deficiency mif-/-, overview. Reduced development of benzo[alpha]pyrene-induced skin tumors in mif-deficient mice
R194Q
-
slaty mutation, 3fold reduction in enzyme activity compared to wild-type. Increase in pheomelanin and reduction in eumelanin produced by melanocytes in culture
additional information
-
modification of Pro1, e.g. via isothiocyanate inhibitors, alters the tertiary, but not the secondary or quaternary, structure of the trimer without affecting its thermodynamic stability, overview
additional information
-
preparation of biotin-isothiocyanate-labeled enzyme, proteomic screening in recombinant HeLa cells and identification of the modification site by mass spectrometry
additional information
-
enzyme knockout mutant, animals are viable and do not show any abnormalities in skin, retinal pigment epithelium, or brain. Animals show a diluted coat colour phenotype due to reduced melanin content in hair. Primary melanocytes from knockout animals are viable in culture and show a normal distribution of tyrosinase and tyrosinase-related protein 1