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BRENDA support

Literature summary for 5.3.3.12 extracted from

  • Costin, G.E.; Valencia, J.C.; Wakamatsu, K.; Ito, S.; Solano, F.; Milac, A.L.; Vieira, W.D.; Yamaguchi, Y.; Rouzaud, F.; et al.
    Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein (2005), Biochem. J., 391, 249-259.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
G486R slaty light mutation, 28fold reduction in enzyme activity, sliding of transmembrane domain towards N-terminus of protein thus interfering with the active site. Increase in pheomelanin and reduction in eumelanin produced by melanocytes in culture Mus musculus
R194Q slaty mutation, 3fold reduction in enzyme activity compared to wild-type. Increase in pheomelanin and reduction in eumelanin produced by melanocytes in culture Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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newborn congenic C57BL/6J non-agouti black mice
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Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
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Mus musculus
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skin
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Mus musculus
-