Protein Variants | Comment | Organism |
---|---|---|
G486R | slaty light mutation, 28fold reduction in enzyme activity, sliding of transmembrane domain towards N-terminus of protein thus interfering with the active site. Increase in pheomelanin and reduction in eumelanin produced by melanocytes in culture | Mus musculus |
R194Q | slaty mutation, 3fold reduction in enzyme activity compared to wild-type. Increase in pheomelanin and reduction in eumelanin produced by melanocytes in culture | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
newborn congenic C57BL/6J non-agouti black mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanocyte | - |
Mus musculus | - |
skin | - |
Mus musculus | - |