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5.3.3.12: L-dopachrome isomerase

This is an abbreviated version!
For detailed information about L-dopachrome isomerase, go to the full flat file.

Word Map on EC 5.3.3.12

Reaction

L-Dopachrome
=
5,6-Dihydroxyindole-2-carboxylate

Synonyms

brown (b) locus protein, D-dopachrome isomerase, D-dopachrome tautomerase, D-DT, DCF, DCT, DDT, dopachrome conversion factor, dopachrome delta-isomerase, dopachrome DELTA7-DELTA2-isomerase, dopachrome oxidoreductase, dopachrome tautomerase, dopachrome-rearranging enzyme, isomerase, dopachrome DELTA-, L-dopachchrome-methyl ester tautomerase, macrophage inhibitory factor, Macrophage migration inhibitory factor, macrophage migration-inhibitory factor, MIF, Mif-2, SLATY locus protein, TRP-2, TRP2, tyrosine-related protein 2

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.12 L-dopachrome isomerase

Expression

Expression on EC 5.3.3.12 - L-dopachrome isomerase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
carbon tetrachloride treatment of livers lead to a 12fold increased expression level of dopachrome tautomerase in male rats, proteomic analysis, overview. The increase in DDT is a response to liver damage, accelerates melanin biosynthesis and protects the liver from oxidative stress induced by CCl4
enzyme protein levels and mRNA expression are significantly decreased in subcutaneous adipose tissue adjacent to acutely inflamed wounds
-
MIF expression is upregulated by cytokines, TNF-alpha and interleukin-I, and by bacterial endotoxins, such as lipopolysaccharides, and exotoxins
-
the enzyme is induced by low levels of glucocorticoids in vitro and in vivo
the enzyme is secreted by the heart after ischemic stress
-