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Literature summary for 5.3.3.12 extracted from

  • Jiang, S.; Liu, X.M.; Dai, X.; Zhou, Q.; Lei, T.C.; Beermann, F.; Wakamatsu, K.; Xu, S.Z.
    Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation (2010), Free Radic. Biol. Med., 48, 1144-1151.
    View publication on PubMed
Search for more literature for 5.3.3.12

Cloned(Commentary)

Cloned (Comment) Organism
Dct genotyping Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-dopachrome Mus musculus Dct isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid, DHICA, and influences the proportion of DHICA monomer incorporated into the 5,6-dihydroxyindole, DHI, polymer in eumelanin 5,6-dihydroxyindole-2-carboxylate DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin. DHICA exhibits a potent hydroxyl radical-scavenging activity when bound to melanin, while DHI-melanin does not ?
L-dopachrome Mus musculus C57BL/6 Dct isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid, DHICA, and influences the proportion of DHICA monomer incorporated into the 5,6-dihydroxyindole, DHI, polymer in eumelanin 5,6-dihydroxyindole-2-carboxylate DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin. DHICA exhibits a potent hydroxyl radical-scavenging activity when bound to melanin, while DHI-melanin does not ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture preparation of single-cell suspensions of the tail skin Mus musculus
-
epidermis
-
 Mus musculus
-
skin
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dopachrome
-
 Mus musculus 5,6-dihydroxyindole-2-carboxylate
-
 ?
L-dopachrome Dct isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid, DHICA, and influences the proportion of DHICA monomer incorporated into the 5,6-dihydroxyindole, DHI, polymer in eumelanin Mus musculus 5,6-dihydroxyindole-2-carboxylate DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin. DHICA exhibits a potent hydroxyl radical-scavenging activity when bound to melanin, while DHI-melanin does not ?
L-dopachrome
-
 Mus musculus C57BL/6 5,6-dihydroxyindole-2-carboxylate
-
 ?
L-dopachrome Dct isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid, DHICA, and influences the proportion of DHICA monomer incorporated into the 5,6-dihydroxyindole, DHI, polymer in eumelanin Mus musculus C57BL/6 5,6-dihydroxyindole-2-carboxylate DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin. DHICA exhibits a potent hydroxyl radical-scavenging activity when bound to melanin, while DHI-melanin does not ?

Synonyms

Synonyms Comment Organism
DCT
-
 Mus musculus
dopachrome tautomerase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Dct inactivation elevates the level of ROS, increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation Mus musculus
physiological function Dct is a critical enzyme in the melanogenesis pathway. It is involved in regulation of DHICA-mediated antioxidation and protection of the skin against UVA radiation Mus musculus