4.2.3.3: methylglyoxal synthase
This is an abbreviated version!
For detailed information about methylglyoxal synthase, go to the full flat file.
Word Map on EC 4.2.3.3
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4.2.3.3
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meibomian
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glass
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film
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tear
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ocular
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eyelid
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gather
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grading
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grimace
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saccade
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dihydroxyacetone
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mongolian
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gerbil
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glory
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microgels
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monoglycerides
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dropout
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break-up
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1,2-propanediol
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ductility
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schirmer
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sire
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dhap
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polydactyly
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alloy
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phantom
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corrosion
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microtia
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orifice
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encephalocele
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cdt1
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orc6
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pre-replication
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synthesis
- 4.2.3.3
-
meibomian
-
glass
-
film
- tear
-
ocular
-
eyelid
-
gather
-
grading
-
grimace
-
saccade
- dihydroxyacetone
-
mongolian
- gerbil
-
glory
-
microgels
- monoglycerides
-
dropout
-
break-up
- 1,2-propanediol
-
ductility
-
schirmer
-
sire
- dhap
- polydactyly
-
alloy
-
phantom
-
corrosion
- microtia
-
orifice
- encephalocele
- cdt1
- orc6
-
pre-replication
- synthesis
Reaction
Synonyms
EC 4.2.99.11, methylglyoxal synthase, methylglyoxal synthetase, MGS, MgsA, msgA, synthase, methylglyoxal
ECTree
4.2.3.3 methylglyoxal synthaseAdvanced search results
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Substrates Products on EC 4.2.3.3 - methylglyoxal synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycerone phosphate
pyruvaldehyde + phosphate
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tautomerization to methylglyoxal
-
?
dihydroxyacetone phosphate
?
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first enzyme in the reaction sequence for the conversion of dihydroxyacetone phosphate to pyruvate, may play a role in the control of glycolysis
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-
?
dihydroxyacetone phosphate
?
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during elevated metabolism, the synthesis of methylglyoxal from dihydroxyacetone phosphate temporarily relieves the cells from stress caused by phosphorylated intermediates and allows the cells to grow for a limited time. If during this period the environment changes, e.g. the level of the carbon source is reduced, the cells are not only able to survive but are also able to colonize their environment
-
-
?
dihydroxyacetone phosphate
?
-
the enzyme plays an important role in the catabolism of the triose phosphates
-
-
?
dihydroxyacetone phosphate
?
-
first enzyme in the reaction sequence for the conversion of dihydroxyacetone phosphate to pyruvate, may play a role in the control of glycolysis
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-
?
dihydroxyacetone phosphate
?
-
the enzyme is involved in the methylglyoxal by-pass
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-
?
dihydroxyacetone phosphate
?
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constitutive enzyme, may be involved in by-pass sequence for part of the Embden-Meyerhof glycolytic pathway
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-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
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strictly specific for
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?
dihydroxyacetone phosphate
methylglyoxal + phosphate
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-
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
the true product of the enzymatic reaction is the enol form of methylglyoxal which is ketonized in solution
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
catalyzes the elimination reaction of DHAP, which leads to phosphate and the enol of methylglyoxal, which is subsequently tautomerized to methylglyoxal in solution
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?
dihydroxyacetone phosphate
methylglyoxal + phosphate
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converts dihydrocyacetone phosphate to a cis-enediolic intermediate, then catalyses the elimination of phosphate to form the enol of methylglyoxal
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?
dihydroxyacetone phosphate
methylglyoxal + phosphate
converts dihydrocyacetone phosphate to enol pyruvaldehyde, this enol then tautomerizes to methylglyoxal in solution
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?
dihydroxyacetone phosphate
methylglyoxal + phosphate
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intermediate is enol pyruvaldehyde is stereospecifically formed
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?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
strictly specific for
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
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since the enzyme accepts the trans-enediol-phosphate as a substrate, it is likely that it or the trans-enediolate is an intermediate in the catalytic reaction with dihydroxyacetone phosphate
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
strictly specific for
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
-
?
dihydroxyacetone phosphate
methylglyoxal + phosphate
-
-
-
?
glycerone phosphate
methylglyoxal + phosphate
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the unregulated production of methylglyoxal appears to be due to a rapid increase in the glycolysis intermediates from ribose degradation. Such a metabolic burden may result in methylglyoxal production by methylglyoxal synthase
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-
?
additional information
?
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enzyme dos no catalyze the elimination reaction with glyceraldehyde phosphate
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?
additional information
?
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enzyme is not capable of abstracting the C2 proton from glyceraldehyde phosphate, which is an absolute requirement for the function of MGS
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?
