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4.2.3.3: methylglyoxal synthase

This is an abbreviated version!
For detailed information about methylglyoxal synthase, go to the full flat file.

Word Map on EC 4.2.3.3

Reaction

glycerone phosphate
=
2-oxopropanal
 +
phosphate

Synonyms

EC 4.2.99.11, methylglyoxal synthase, methylglyoxal synthetase, MGS, MgsA, msgA, synthase, methylglyoxal

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.3 methylglyoxal synthase

Reference

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Reference on EC 4.2.3.3 - methylglyoxal synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hopper, D.J.; Cooper, R.A.
The regulation of Escherichia coli methylglyoxal synthase a new control site in glycolysis
FEBS Lett.
13
213-216
1971
Klebsiella aerogenes, Escherichia coli, Pantoea ananatis, Providencia rettgeri, Proteus vulgaris, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Proteus vulgaris M 13, Providencia rettgeri M 9, Escherichia coli K 10, Klebsiella aerogenes SB 8, Serratia marcescens D 106
Manually annotated by BRENDA team
Hopper, D.J.; Cooper, R.A.
The purification and properties of Escherichia coli methylglyoxal synthase
Biochem. J.
128
321-329
1972
Escherichia coli
Manually annotated by BRENDA team
Cooper, R.A.
Methylglyoxal formation during glucose catabolism by Pseudomonas saccharophila. Identification of methylglyoxal synthase
Eur. J. Biochem.
44
81-86
1974
Pelomonas saccharophila
Manually annotated by BRENDA team
Cooper, R.A.
Methylglyoxal synthase
Methods Enzymol.
41B
502-508
1975
Aeromonas caviae, Clostridium pasteurianum, Clostridium tetanomorphum, Obesumbacterium proteus, Pelomonas saccharophila
Manually annotated by BRENDA team
Tsai, P.K.; Gracy, R.W.
Isolation and characterization of crystalline methylglyoxal synthetase from Proteus vulgaris
J. Biol. Chem.
251
364-367
1976
Proteus vulgaris
Manually annotated by BRENDA team
Yuan, P.M.; Gracy, R.W.; Hartman, F.C.
Haloacetol phosphates as affinity labels for methylglyoxal synthase
Biochem. Biophys. Res. Commun.
74
1007-1013
1977
Proteus vulgaris
Manually annotated by BRENDA team
Summers, M.C.; Rose, I.A.
Proton transfer reactions of methylglyoxal synthase
J. Am. Chem. Soc.
99
4475-4478
1977
Escherichia coli
Manually annotated by BRENDA team
Yuan, P.M.; Gracy, R.W.
The conversion of dihydroxyacetone phosphate to methylglyoxal and inorganic phosphate by methylglyoxal synthase
Arch. Biochem. Biophys.
183
1-6
1977
Proteus vulgaris
Manually annotated by BRENDA team
Ray, S.; Ray, M.
Isolation of methylglyoxal synthase from goat liver
J. Biol. Chem.
256
6230-6233
1981
Capra hircus
Manually annotated by BRENDA team
Smits, M.M.; Johnson, M.A.
Methylglyoxal: enzyme distributions relative to its presence in Douglas-fir needles and absence in Douglas-fir needle callus
Arch. Biochem. Biophys.
208
431-439
1981
Pseudotsuga menziesii, Pseudotsuga menziesii Mirb.
Manually annotated by BRENDA team
Iyengar, R.; Rose, I.A.
Methylglyoxal synthase uses the trans isomer or triose-1,2-enediol 3-phosphate
J. Am. Chem. Soc.
105
3301-3303
1983
Proteus vulgaris
-
Manually annotated by BRENDA team
Tran-Din, K.; Gottschalk, G.
Formation of D(-)-1,2-propanediol and D(-)-lactate from glucose by Clostridium sphenoides under phosphate limitation
Arch. Microbiol.
142
87-92
1985
Lacrimispora sphenoides
-
Manually annotated by BRENDA team
Murata, K.; Fukuda, Y.; Watanabe, K.; Saikusa, T.; Shimosaka, M.; Kimura, A.
Characterization of methylglyoxal synthase in Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
131
190-198
1985
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ferguson, G.P.; Tötemeyer, S.; MacLean, M.J.; Booth, I.R.
Methylglyoxal production in bacteria: suicide or survival
Arch. Microbiol.
170
209-219
1998
Escherichia coli
Manually annotated by BRENDA team
Baskaran, S.; Rajan, D.P.; Balasubramanian, K.A.
Formation of methylglyoxal by bacteria isolated from human faeces
J. Med. Microbiol.
28
211-215
1989
Aeromonas hydrophila, Escherichia coli, Klebsiella sp., Morganella morganii, Proteus mirabilis, Proteus vulgaris, Salmonella sp., Shigella sp.
Manually annotated by BRENDA team
Huang, K.X.; Rudolph, F.B.; Bennett, G.N.
Characterization of methylglyoxal synthase from Clostridium acetobutylicum ATCC 824 and its use in the formation of 1,2-propanediol
Appl. Environ. Microbiol.
65
3244-3247
1999
Clostridium acetobutylicum
Manually annotated by BRENDA team
Saadat, D.; Harrison, D.H.T.
Identification of catalytic bases in the active site of Escherichia coli methylglyoxal synthase: cloning, expression, and functional characterization of conserved aspartic acid residues
Biochemistry
37
10074-10086
1998
Escherichia coli
Manually annotated by BRENDA team
Altaras, N.E.; Cameron, D.C.
Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli
Appl. Environ. Microbiol.
65
1180-1185
1999
Escherichia coli
Manually annotated by BRENDA team
Tötemeyer, S.; Booth, N.A.; Nichols, W.W.; Dunbar, B.; Booth, I.R.
From famine to feast: the role of methylglyoxal production in Escherichia coli
Mol. Microbiol.
27
553-562
1998
Escherichia coli
Manually annotated by BRENDA team
Saadat, D.; Harrison, D.H.
Mirroring perfection: the structure of methylglyoxal synthase complexed with the competitive inhibitor 2-phosphoglycolate
Biochemistry
39
2950-2960
2000
Escherichia coli (P0A731)
Manually annotated by BRENDA team
Marks, G.T.; Harris, T.K.; Massiah, M.A.; Mildvan, A.S.; Harrison, D.H.
Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy
Biochemistry
40
6805-6818
2001
Escherichia coli
Manually annotated by BRENDA team
Marks, G.T.; Susler, M.; Harrison, D.H.
Mutagenic studies on histidine 98 of methylglyoxal synthase: effects on mechanism and conformational change
Biochemistry
43
3802-3813
2004
Escherichia coli (P0A731)
Manually annotated by BRENDA team
Rose, I.A.; Nowick, J.S.
Methylglyoxal synthetase, enol-pyruvaldehyde, glutathione and the glyoxylase system
J. Am. Chem. Soc.
124
13047-13052
2002
Escherichia coli
Manually annotated by BRENDA team
Zhang, X.; Harrison, D.H.; Cui, Q.
Functional specificities of methylglyoxal synthase and triosephosphate isomerase: a combined QM/MM analysis
J. Am. Chem. Soc.
124
14871-14878
2002
Escherichia coli (P0A731)
Manually annotated by BRENDA team
Saadat, D.; Harrison, D.H.
The crystal structure of methylglyoxal synthase from Escherichia coli
Structure Fold. Des.
7
309-317
1999
Escherichia coli
Manually annotated by BRENDA team
Kim, I.; Kim, E.; Yoo, S.; Shin, D.; Min, B.; Song, J.; Park, C.
Ribose utilization with an excess of mutarotase causes cell death due to accumulation of methylglyoxal
J. Bacteriol.
186
7229-7235
2004
Escherichia coli
Manually annotated by BRENDA team
Grabar, T.B.; Zhou, S.; Shanmugam, K.T.; Yomano, L.P.; Ingram, L.O.
Methylglyoxal bypass identified as source of chiral contamination in l(+) and d(-)-lactate fermentations by recombinant Escherichia coli
Biotechnol. Lett.
28
1527-1535
2006
Escherichia coli (P0A731)
Manually annotated by BRENDA team
Pazhang, M.; Khajeh, K.; Asghari, S.M.; Falahati, H.; Naderi-Manesh, H.
Cloning, expression, and characterization of a novel methylglyoxal synthase from Thermus sp. strain GH5
Appl. Biochem. Biotechnol.
162
1519-1528
2010
Thermus sp. GH5 (B3VH91)
Manually annotated by BRENDA team
Yomano, L.P.; York, S.W.; Shanmugam, K.T.; Ingram, L.O.
Deletion of methylglyoxal synthase gene (mgsA) increased sugar co-metabolism in ethanol-producing Escherichia coli
Biotechnol. Lett.
31
1389-1398
2009
Escherichia coli, Escherichia coli LY160
Manually annotated by BRENDA team
Niimi, S.; Suzuki, N.; Inui, M.; Yukawa, H.
Metabolic engineering of 1,2-propanediol pathways in Corynebacterium glutamicum
Appl. Microbiol. Biotechnol.
90
1721-1729
2011
Escherichia coli
Manually annotated by BRENDA team
Clomburg, J.M.; Gonzalez, R.
Metabolic engineering of Escherichia coli for the production of 1,2-propanediol from glycerol
Biotechnol. Bioeng.
108
867-879
2011
Escherichia coli
Manually annotated by BRENDA team
Mohammadi, M.; Kashi, M.A.; Zareian, S.; Mirshahi, M.; Khajeh, K.
Remarkable improvement of methylglyoxal synthase thermostability by His-His interaction
Appl. Biochem. Biotechnol.
172
157-167
2014
Thermus sp. (B3VH91)
Manually annotated by BRENDA team
Zareian, S.; Khajeh, K.; Pazhang, M.; Ranjbar, B.
Rationalization of allosteric pathway in Thermus sp. GH5 methylglyoxal synthase
BMB Rep.
45
748-753
2012
Thermus sp. (B3VH91)
Manually annotated by BRENDA team
Farsi, Z.; Pein, H.; Pazhang, M.; Zareian, S.; Ranaei-Siadat, S.O.; Khajeh, K.
Conferral of allostery to Thermus sp. GH5 methylglyoxal synthase by a single mutation
J. Biochem.
152
531-538
2012
Thermus sp. (B3VH91)
Manually annotated by BRENDA team
Mohammadi, M.; Zareian, S.; Khajeh, K.
Conversion of non-allosteric methylglyoxal synthase into a homotropic allosteric enzyme by C-terminal deletion
J. Mol. Catal. B
107
95-99
2014
Escherichia coli
-
Manually annotated by BRENDA team
Falahati, H.; Pazhang, M.; Zareian, S.; Ghaemi, N.; Rofougaran, R.; Hofer, A.; Rezaie, A.; Khajeh, K.
Transmitting the allosteric signal in methylglyoxal synthase
Protein Eng. Des. Sel.
26
445-452
2013
Thermus sp. (B3VH91)
Manually annotated by BRENDA team
Atabakhshi-Kashi, M.; Mohammadi, M.; Mirhassani, R.; Dabirmanesh, B.; Sajedi, R.H.; Khajeh, K.
An alternative allosteric pathway in thermophilic methylglyoxal synthase
Int. J. Biol. Macromol.
93
526-533
2016
Thermus sp. GH5 (B3VH91)
Manually annotated by BRENDA team
Dickmanns, A.; Zschiedrich, C.P.; Arens, J.; Parfentev, I.; Gundlach, J.; Hofele, R.; Neumann, P.; Urlaub, H.; Goerke, B.; Ficner, R.; Stuelke, J.
Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis
J. Biol. Chem.
293
5781-5792
2018
Bacillus subtilis (P42980), Bacillus subtilis 168 (P42980)
Manually annotated by BRENDA team