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4.2.3.3: methylglyoxal synthase

This is an abbreviated version!
For detailed information about methylglyoxal synthase, go to the full flat file.

Word Map on EC 4.2.3.3

Reaction

glycerone phosphate
=
2-oxopropanal
 +
phosphate

Synonyms

EC 4.2.99.11, methylglyoxal synthase, methylglyoxal synthetase, MGS, MgsA, msgA, synthase, methylglyoxal

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.3 methylglyoxal synthase

Inhibitors

Inhibitors on EC 4.2.3.3 - methylglyoxal synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3-diphosphoglycerate
-
-
2-mercaptoethanol
-
-
2-phosphoglycerate
2-Phosphoglycolate
inhibits
3-bromoacetol phosphate
-
irreversible inactivation by reacting with a nucleophilic group located in the active center, dihydroxyacetone phosphate or phosphate protects
3-chloroacetol phosphate
-
competitive
3-iodoacetol phosphate
-
irreversible inactivation by reacting with a nucleophilic group located in the active center, dihydroxyacetone phosphate or phosphate protects
3-phosphoglycerate
arsenate
-
-
Crh protein
in the absence of preferred carbon sources, the phosphoprotein Crh is present in the nonphosphorylated state and binds to and thereby inhibits the enzyme
-
diphosphate
fructose 1,6-diphosphate
glucose 1-phosphate
-
-
glucose 6-phosphate
-
-
glyceraldehyde 3-phosphate
-
-
methylglyoxal
-
linear noncompetitive inhibitor
phosphate
phosphoenolpyruvate
Phosphoglycolate
inhibits wild-type enzyme and activates H98Q variant
phosphoglycolohydroxamic acid
-
tight binding inhibitor, neither a strictly competitive, non-competitive, nor uncompetitive mechanism
additional information
-
no inactivation by iodoacetate or p-mercuribenzoate
-