4.2.3.3: methylglyoxal synthase
This is an abbreviated version!
For detailed information about methylglyoxal synthase, go to the full flat file.
Word Map on EC 4.2.3.3
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4.2.3.3
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meibomian
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glass
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film
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tear
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ocular
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eyelid
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gather
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grading
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grimace
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saccade
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dihydroxyacetone
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mongolian
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gerbil
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glory
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microgels
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monoglycerides
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dropout
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break-up
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1,2-propanediol
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ductility
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schirmer
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sire
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dhap
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polydactyly
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alloy
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phantom
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corrosion
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microtia
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orifice
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encephalocele
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cdt1
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orc6
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pre-replication
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synthesis
- 4.2.3.3
-
meibomian
-
glass
-
film
- tear
-
ocular
-
eyelid
-
gather
-
grading
-
grimace
-
saccade
- dihydroxyacetone
-
mongolian
- gerbil
-
glory
-
microgels
- monoglycerides
-
dropout
-
break-up
- 1,2-propanediol
-
ductility
-
schirmer
-
sire
- dhap
- polydactyly
-
alloy
-
phantom
-
corrosion
- microtia
-
orifice
- encephalocele
- cdt1
- orc6
-
pre-replication
- synthesis
Reaction
Synonyms
EC 4.2.99.11, methylglyoxal synthase, methylglyoxal synthetase, MGS, MgsA, msgA, synthase, methylglyoxal
ECTree
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Application
Application on EC 4.2.3.3 - methylglyoxal synthase
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synthesis
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strains in which the genes for glycerol dehydrogenase, methylglyoxal synthase or both are overexpressed produce 1,2-propanediol as a fermentation product of glucose
synthesis
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engineering of a functional 1,2-propanediol pathway through a combination of overexpression of genes involved in its synthesis from the key intermediate dihydroxyacetone phosphate and the manipulation of the fermentative glycerol utilization pathway, including the overexpression of methylglyoxal synthase, glycerol dehydrogenase, and aldehyde oxidoreductase. Rreplacement of the native Escherichia coli phosphoenolpyruvate-dependent dihydroxyacetone kinase with an ATP-dependent ihydroxyacetone kinase from Citrobacter freundii allows for higher 1,2-propanediol production. Ethanol is required as co-product, and inreases in 1,2-PDO titer and yield are achieved through the disruption of the pathways for acetate and lactate production. Manipulations result in an engineered Escherichia coli strain capable of producing 5.6 g/l 1,2-propanediol, at a yield of 21.3% w/w. This strain also performs well when crude glycerol is used as the substrate
synthesis
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expressing Escherichia coli mgs gene in Corynebacterium glutamicum increases 1,2-propanediol yield 100fold. Simultaneous overexpression of mgs and cgR_2242, annotated as encoding putative aldo-keto reductase, enhances 1,2-propanediol production to 24 mM