3.6.1.59: 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
This is an abbreviated version!
For detailed information about 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.59
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3.6.1.59
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heterodimer
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m7gdp
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disability
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nucleoside
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hint
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exosome
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diauxie
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craniofacial
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trehalase
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exonucleolytic
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intellectual
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medicine
- 3.6.1.59
- heterodimer
- m7gdp
- disability
- nucleoside
-
hint
-
exosome
-
diauxie
-
craniofacial
- trehalase
-
exonucleolytic
-
intellectual
- medicine
Reaction
Synonyms
Dcps, Dcs1, EC 3.6.1.30, m7GpppN m7GMP phosphohydrolase, m7GpppX pyrophosphatase, scavenger mRNA decapping enzyme, yDcps, YLR270W
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General Information
General Information on EC 3.6.1.59 - 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
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malfunction
physiological function
depletion of Dcs1, reduces chronological life span, possibly by modulating m7G misincorporation into nucleic acids. This can potentially link control of mRNA metabolism with senescence
malfunction
disruption of the DCS1 gene manifests a threefold increase of the TIF51A mRNA half-life. 5' to 3' exoribonucleolytic activity is impeded in the dcs1DELTAstrain, resulting in the accumulation of uncapped mRNA
DcpS is a molecule that modulates cap concentrations for cellular homeostasis of gene expression activities involving at least RNA processing. A nuclear function for DcpS in maintaining proper pre-mRNA splicing
physiological function
eukaryotic cells utilize DcpS, a scavenger decapping enzyme, to degrade the residual cap structure following 30-50 mRNA decay, thereby preventing the premature decapping of the capped long mRNA and misincorporation of methylated nucleotides in nucleic acids
physiological function
eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce 7-methylguanosine 5'-diphosphate and 5'-phosphorylated mRNA