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Literature summary for 3.6.1.59 extracted from

  • van Dijk, E.; Le Hir, H.; Séraphin, B.
    DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway (2003), Proc. Natl. Acad. Sci. USA, 100, 12081-12086.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.59

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7-methylguanosine 5'-diphosphate + H2O Homo sapiens eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA 7-methylguanosine 5'-phosphate + phosphate
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 ?
m7G5'ppp5'N(3'ppp5'N)n + H2O Homo sapiens n = 1-8, eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96C86
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-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methylguanosine 5'-diphosphate + H2O
-
 Homo sapiens 7-methylguanosine 5'-phosphate + phosphate
-
 ?
7-methylguanosine 5'-diphosphate + H2O eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA Homo sapiens 7-methylguanosine 5'-phosphate + phosphate
-
 ?
m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8 Homo sapiens 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
-
 ?
m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8, eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA Homo sapiens 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
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 ?

Synonyms

Synonyms Comment Organism
Dcps
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce 7-methylguanosine 5'-diphosphate and 5'-phosphorylated mRNA Homo sapiens