3.6.1.59: 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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For detailed information about 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase, go to the full flat file.

Reaction

Synonyms

Dcps, Dcs1, EC 3.6.1.30, m7GpppN m7GMP phosphohydrolase, m7GpppX pyrophosphatase, scavenger mRNA decapping enzyme, yDcps, YLR270W

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.59 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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Results	in table
1086	AA Sequence
1	Application
4	Cloned(Commentary)
3	Crystallization (Commentary)
2	Disease/ Diagnostics
5	General Information
2	IC50 Value
6	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
4	Localization
1	Metals/Ions
2	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
15	Organism
22	PDB ID
3	pH Optimum
1	pI Value
7	Purification (Commentary)
2	Reaction
15	Reference
2	Source Tissue
58	Substrates and Products (Substrate)
5	Subunits
20	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.6.1.59 - 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

C5-substituted quinazolines

Homo sapiens

Q96C86

C5-quinazolines potently inhibit DcpS decapping activity. Binding of C5-substituted quinazolines to DcpS holds the enzyme in an open, catalytically incompetent conformation

713604

-

D156844

Homo sapiens

Q96C86

highly effective at inhibiting recombinant DcpS decapping activity

713604

Dcs2 protein

Saccharomyces cerevisiae

Q06151

Dcs2 is recruited into cytoplasmic P bodies, its inhibitory function may be focused in these centres of mRNA storage/turnover. Dcs2 is a stress-induced regulatory protein that modulates m7GpppX pyrophosphatase activity

688336

-

KCl

Saccharomyces cerevisiae

-

the decapping reaction is significantly inhibited by increasing salt concentration, with KCl being a more potent inhibitor than NaCl

758456

m7G5'ppp5'G

Homo sapiens

Q96C86

-

713604

NaCl

Saccharomyces cerevisiae

-

the decapping reaction is significantly inhibited by increasing salt concentration, with KCl being a more potent inhibitor than NaCl

758456