3.6.1.59: 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

This is an abbreviated version!
For detailed information about 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase, go to the full flat file.

Reaction

Synonyms

Dcps, Dcs1, EC 3.6.1.30, m7GpppN m7GMP phosphohydrolase, m7GpppX pyrophosphatase, scavenger mRNA decapping enzyme, yDcps, YLR270W

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.59 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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1086	AA Sequence
1	Application
4	Cloned(Commentary)
3	Crystallization (Commentary)
2	Disease/ Diagnostics
5	General Information
2	IC50 Value
6	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
4	Localization
1	Metals/Ions
2	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
15	Organism
22	PDB ID
3	pH Optimum
1	pI Value
7	Purification (Commentary)
2	Reaction
15	Reference
2	Source Tissue
58	Substrates and Products (Substrate)
5	Subunits
20	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

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Natural Substrates Products on EC 3.6.1.59 - 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

7-methylguanosine 5'-diphosphate + H2O

7-methylguanosine 5'-phosphate + phosphate

4 entries

a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O

N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]

Saccharomyces cerevisiae

-

the enzyme decaps RNA transcripts as long as 1400 nucleotides

758456

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

7 entries

7-methylguanosine 5'-diphosphate + H2O

7-methylguanosine 5'-phosphate + phosphate

Homo sapiens

Q96C86

-

716897

-

-

?

7-methylguanosine 5'-diphosphate + H2O

7-methylguanosine 5'-phosphate + phosphate

Homo sapiens

Q96C86

eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA

716801

-

-

?

7-methylguanosine 5'-diphosphate + H2O

7-methylguanosine 5'-phosphate + phosphate

Saccharomyces cerevisiae

Q06151

cleavage of 7-methylguanosine 5'-diphosphate generated by Dcp1/Dcp2-mediated decapping in the 5' to 3' decay pathway

688336

-

-

?

7-methylguanosine 5'-diphosphate + H2O

7-methylguanosine 5'-phosphate + phosphate

Saccharomyces cerevisiae

Q06151

mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7G5'ppp5'N cap dinucleotide, which is subsequently hydrolyzed to m7Gp and nucleotidyl 5'-diphosphate in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p

716209

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Homo sapiens

Q96C86

eukaryotic cells utilize DcpS, a scavenger decapping enzyme, to degrade the residual cap structure following 30-50 mRNA decay, thereby preventing the premature decapping of the capped long mRNA and misincorporation of methylated nucleotides in nucleic acids

715901

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Homo sapiens

Q96C86

n = 1-8

713604, 714825, 716897

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Homo sapiens

Q96C86

n = 1-8, decapping is an important process in the control of eukaryotic mRNA degradation. The scavenger decapping enzyme DcpS functions to clear the cell of cap structure following decay of the RNA body by catalyzing the hydrolysis of m7GpppN to m7Gp and ppN

715492

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Homo sapiens

Q96C86

n = 1-8, eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA

716801

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Saccharomyces cerevisiae

Q06151

cleavage of 5' end m7G-oligoribonucleotide fragments generated by 3' to 5' exonucleolytic decay

688336

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Saccharomyces cerevisiae

Q06151

n = 1-8

714825

-

-

?

m7G5'ppp5'N(3'ppp5'N)n + H2O

7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n

Saccharomyces cerevisiae

Q06151

n = 1-8, mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7GpppN cap dinucleotide, which is subsequently hydrolyzed to m7Gp and ppN in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p

716209

-

-

?