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3.6.1.59: 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

This is an abbreviated version!
For detailed information about 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.59

Reaction

a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]
+
H2O
=
N7-methylguanosine 5'-phosphate
 +
a 5'-diphospho-[mRNA]

Synonyms

Dcps, Dcs1, EC 3.6.1.30, m7GpppN m7GMP phosphohydrolase, m7GpppX pyrophosphatase, scavenger mRNA decapping enzyme, yDcps, YLR270W

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.59 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

KM Value

KM Value on EC 3.6.1.59 - 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00026
7-methylguanosine 5'-diphosphate
pH 7.0, 30°C, Dcs1 homodimer
0.00014
m7G5'ppp5'G
pH 7.0, 30°C, Dcs1 homodimer
additional information
additional information
DcpS exhibits different enzymatic kinetics under low and high substrate conditions, negative cooperativity between two wild type subunits, reduced decapping activity is displayed by the DcpSWT/HIT heterodimer under high substrate conditions
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