3.5.1.15: aspartoacylase
This is an abbreviated version!
For detailed information about aspartoacylase, go to the full flat file.
Word Map on EC 3.5.1.15
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3.5.1.15
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canavan
-
n-acetylaspartate
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leukodystrophy
-
matter
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myelin
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oligodendrocyte
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spongy
-
n-acetyl-l-aspartate
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spongiform
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macrocephaly
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tremor
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ashkenazi
-
jewish
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non-jewish
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dysmyelination
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nutrition
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medicine
-
pharmacology
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n-acetylaspartylglutamate
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triacetate
- 3.5.1.15
- canavan
- n-acetylaspartate
- leukodystrophy
- matter
- myelin
- oligodendrocyte
-
spongy
- n-acetyl-l-aspartate
-
spongiform
- macrocephaly
- tremor
-
ashkenazi
-
jewish
-
non-jewish
-
dysmyelination
- nutrition
- medicine
- pharmacology
- n-acetylaspartylglutamate
- triacetate
Reaction
Synonyms
acetyl-aspartic deaminase, Acylase II, aminoacylase 2, Aminoacylase II, aminoacylase-2, ASPA, aspartic acid acylase, Aspartoacylase, aspartoacylase II, hASPA, human ASPA, More, murine aspartoacylase, N-acetyl-aspartate deacetylase, N-Acetyl-L-aspartate amidohydrolase, N-Acetylaspartate amidohydrolase, N-acetylaspartocylase, NAA acylase
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Reference on EC 3.5.1.15 - aspartoacylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
D'Adamo, A.F.; Wertman, E.; Foster, F.; Schneider, H.
A radiochemical assay for N-acetyl-L-aspartate amidohydrolase (EC 3.5.1.15) and its occurrence in the tissues of the chicken
Life Sci.
23
791-796
1978
Columba sp., Gallus sp., no activity in Cavia porcellus, Rattus norvegicus
Endo, Y.
Deacetylation and deformylation of N-acyl amino acids by kidney acylases
FEBS Lett.
95
281-283
1978
Cavia porcellus, Rattus norvegicus, Rattus norvegicus Wistar
D'Adamo, A.F.; Peisach, J.; Manner, G.; Weiler, C.T.
N-Acetyl-aspartate amidohydrolase: Purification and properties
J. Neurochem.
28
739-744
1977
Gallus sp., Rattus norvegicus, Sus scrofa
Goldstein, F.B.
Amidohydrolases of brain; enzymatic hydrolysis of N-acetyl-L-aspartate and other N-acyl-L-amino acids
J. Neurochem.
26
45-49
1976
Bos taurus, Columba sp., Oryctolagus cuniculus, Felis catus, Macaca iris, Macaca mulatta, Mesocricetus auratus, Mus musculus, no activity in Cavia porcellus, Rattus norvegicus, Sus scrofa, Rattus norvegicus Sprague Dawley
D'Adamo, A.F.; Smith, J.C.; Weiler, C.
The occurrence of N-acetylaspartate amidohydrolase (aminoacylase II) in the developing rat
J. Neurochem.
20
1275-1278
1973
Rattus norvegicus, Sus scrofa, Rattus norvegicus Sprague Dawley
Birnbaum, S.M.
Aminoacylase amino acid acylases I and II from hog kidney
Methods Enzymol.
2
115-119
1955
Sus scrofa
-
Kaul, R.; Casanova, J.; Johnson, A.B.; Tang, P.; Matalon, R.
Purification, characterization, and localization of aspartoacylase from bovine brain
J. Neurochem.
56
129-135
1991
Bos taurus, Homo sapiens
Namboodiri, M.A.A.; Corigliano-Murphy, A.; Jiang, G.; Rollag, M.; Provencio, I.
Murine aspartoacylase: cloning, expression and comparison with the human enzyme
Mol. Brain Res.
77
285-289
2000
Bos taurus, Homo sapiens, Mus musculus (Q8R3P0), Mus musculus, Prochlorococcus marinus
Baslow, M.H.; Suckow, R.F.; Sapirstein, V.; Hungund, B.L.
Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes
J. Mol. Neurosci.
13
47-53
1999
Carassius auratus, Homo sapiens, Rattus norvegicus
Barash, V.; Flhor, D.; Morag, B.; Boneh, A.; Elpeleg, O.N.; Gilon, C.
A radiometric assay for aspartoacylase activity in human fibroblasts: application for the diagnosis of canavan's disease
Clin. Chim. Acta
201
175-182
1991
Homo sapiens, Rattus norvegicus
Birnbaum, S.M.; Levintow, L.; Kingsley, R.B.; Greenstein, J.P.
Specificity of amino acid acylases
J. Biol. Chem.
194
455-470
1952
Sus scrofa
Surendran, S.; Matalon, R.; Tyring, S.K.
Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy
Biochem. Biophys. Res. Commun.
345
973-975
2006
Mus musculus
Le Coq, J.; An, H.J.; Lebrilla, C.; Viola, R.E.
Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease
Biochemistry
45
5878-5884
2006
Homo sapiens
George, R.L.; Huang, W.; Naggar, H.A.; Smith, S.B.; Ganapathy, V.
Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse
Biochim. Biophys. Acta
1690
63-69
2004
Mus musculus
Hershfield, J.R.; Madhavarao, C.N.; Moffett, J.R.; Benjamins, J.A.; Garbern, J.Y.; Namboodiri, A.
Aspartoacylase is a regulated nuclear-cytoplasmic enzyme
FASEB J.
20
2139-2141
2006
Rattus norvegicus
Herga, S.; Berrin, J.G.; Perrier, J.; Puigserver, A.; Giardina, T.
Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease
FEBS Lett.
580
5899-5904
2006
Homo sapiens
Madhavarao, C.N.; Moffett, J.R.; Moore, R.A.; Viola, R.E.; Namboodiri, M.A.; Jacobowitz, D.M.
Immunohistochemical localization of aspartoacylase in the rat central nervous system
J. Comp. Neurol.
472
318-329
2004
Rattus norvegicus
Francis, J.S.; Olariu, A.; McPhee, S.W.; Leone, P.
Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis
J. Neurosci. Res.
84
151-169
2006
Rattus norvegicus (Q9R1T5)
Klugmann, M.; Leichtlein, C.B.; Symes, C.W.; Serikawa, T.; Young, D.; During, M.J.
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease
Mol. Ther.
11
745-753
2005
Homo sapiens, Rattus norvegicus
Le Coq, J.; Pavlovsky, A.; Malik, R.; Sanishvili, R.; Xu, C.; Viola, R.E.
Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue
Biochemistry
47
3484-3492
2008
Homo sapiens (P45381), Homo sapiens
Hershfield, J.R.; Pattabiraman, N.; Madhavarao, C.N.; Namboodiri, M.A.
Mutational analysis of aspartoacylase: implications for Canavan disease
Brain Res.
1148
1-14
2007
Homo sapiens (P45381)
Di Pietro, V.; Gambacurta, A.; Amorini, A.M.; Finocchiaro, A.; DUrso, S.; Ceccarelli, L.; Tavazzi, B.; Giardina, B.; Lazzarino, G.
A new T677C mutation of the aspartoacylase gene encodes for a protein with no enzymatic activity
Clin. Biochem.
41
611-615
2008
Homo sapiens
Wang, J.; Matalon, R.; Bhatia, G.; Wu, G.; Li, H.; Liu, T.; Lu, Z.H.; Ledeen, R.W.
Bimodal occurrence of aspartoacylase in myelin and cytosol of brain
J. Neurochem.
101
448-457
2007
Mus musculus
Surendran, S.
Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility
Mol. Biol. Rep.
345
973-975
2007
Rattus norvegicus
Bitto, E.; Bingman, C.A.; Wesenberg, G.E.; McCoy, J.G.; Phillips, G.N.
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease
Proc. Natl. Acad. Sci. USA
104
456-461
2007
Rattus norvegicus, Homo sapiens (P45381), Homo sapiens
Hanaya, R.; Kiura, Y.; Kurisu, K.; Sakai, N.; Serikawa, T.; Sasa, M.
N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations
Brain Res. Bull.
75
663-667
2008
Rattus norvegicus
Baslow, M.H.; Guilfoyle, D.N.
Are Astrocytes the Missing Link Between Lack of Brain Aspartoacylase Activity and the Spongiform Leukodystrophy in Canavan Disease?
Neurochem. Res.
34
1523-1534
2009
Homo sapiens
Kumar, S.; Biancotti, J.C.; Matalon, R.; de Vellis, J.
Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease
J. Neurosci. Res.
87
3415-3427
2009
Mus musculus
Surendran, S.
Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility
Mol. Biol. Rep.
36
201-206
2009
Rattus norvegicus
Zhang, C.; Liu, X.; Xue, Y.
A general acid-general base reaction mechanism for human brain aspartoacylase: A QM/MM study
Comput. Theoret. Chem.
980
85-91
2012
Homo sapiens (P45381)
-
Durmaz, A.A.; Akin, H.; Onay, H.; Vahabi, A.; Ozkinay, F.
A novel aspartoacylase (ASPA) gene mutation in Canavan disease
Fetal. Pediatr. Pathol.
31
236-239
2012
Homo sapiens
Francis, J.S.; Strande, L.; Markov, V.; Leone, P.
Aspartoacylase supports oxidative energy metabolism during myelination
J. Cereb. Blood Flow Metab.
32
1725-1736
2012
Mus musculus
Zhang, C.H.; Gao, J.Y.; Chen, Z.Q.; Xue, Y.
Molecular dynamics and density functional theory studies of substrate binding and catalysis of human brain aspartoacylase
J. Mol. Graph. Model.
28
799-806
2010
Homo sapiens (P45381), Homo sapiens
Zano, S.; Malik, R.; Szucs, S.; Matalon, R.; Viola, R.E.
Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease
Mol. Genet. Metab.
102
176-180
2011
Homo sapiens
Wang, Q.; Viola, R.E.
Reexamination of aspartoacylase: is this human enzyme really a glycoprotein?
Arch. Biochem. Biophys.
548
66-73
2014
Homo sapiens (P45381), Homo sapiens
Wijayasinghe, Y.S.; Pavlovsky, A.G.; Viola, R.E.
Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective
Biochemistry
53
4970-4978
2014
Homo sapiens (P45381)
Gautier, E.; Ivanov, S.; Williams, J.; Huang, S.; Marcelin, G.; Fairfax, K.; Wang, P.; Francis, J.; Leone, P.; Wilson, D.; Artyomov, M.; Pearce, E.; Randolph, G.
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
J. Exp. Med.
211
1525-1531
2014
Mus musculus (Q8R3P0)
Poddar, N.K.; Zano, S.; Natarajan, R.; Yamamoto, B.; Viola, R.E.
Enhanced brain distribution of modified aspartoacylase
Mol. Genet. Metab.
113
219-224
2014
Homo sapiens (P45381)
Kots, E.D.; Lushchekina, S.V.; Varfolomeev, S.D.; Nemukhin, A.V.
Role of protein dimeric interface in allosteric inhibition of N-acetyl-aspartate hydrolysis by human aspartoacylase
J. Chem. Inf. Model.
57
1999-2008
2017
Homo sapiens (P45381), Homo sapiens
Kots, E.D.; Khrenova, M.G.; Nemukhin, A.V.
Allosteric control of N-acetyl-aspartate hydrolysis by the Y231C and F295S mutants of human aspartoacylase
J. Chem. Inf. Model.
59
2299-2308
2019
Homo sapiens (P45381), Homo sapiens
Khrenova, M.G.; Kots, E.D.; Varfolomeev, S.D.; Lushchekina, S.V.; Nemukhin, A.V.
Three faces of N-acetylaspartate activator, substrate, and inhibitor of human aspartoacylase
J. Phys. Chem. B
121
9389-9397
2017
Homo sapiens (P45381), Homo sapiens
George Priya Doss, C.; Zayed, H.
Comparative computational assessment of the pathogenicity of mutations in the aspartoacylase enzyme
Metab. Brain Dis.
32
2105-2118
2017
Homo sapiens (P45381), Homo sapiens
Kots, E.; Khrenova, M.; Lushchekina, S.; Nemukhin, A.
Mechanisms of the aspartoacylase catalytic activity regulation according to the computer modeling results
Moscow Univ. Chem. Bull.
73
152-154
2018
Homo sapiens (P45381)
-
Kots, E.; Khrenova, M.; Nemukhin, A.; Varfolomeev, S.
Aspartoacylase A central nervous system enzyme. Structure, catalytic activity and regulation mechanisms
Russ. Chem. Rev.
88
1-26
2019
Homo sapiens (P45381)
-
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