3.5.1.15: aspartoacylase

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For detailed information about aspartoacylase, go to the full flat file.

Reaction

Synonyms

acetyl-aspartic deaminase, Acylase II, aminoacylase 2, Aminoacylase II, aminoacylase-2, ASPA, aspartic acid acylase, Aspartoacylase, aspartoacylase II, hASPA, human ASPA, More, murine aspartoacylase, N-acetyl-aspartate deacetylase, N-Acetyl-L-aspartate amidohydrolase, N-Acetylaspartate amidohydrolase, N-acetylaspartocylase, NAA acylase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.15 aspartoacylase

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Results	in table
26	Activating Compound
712	AA Sequence
7	Application
1	CAS Registry Number
17	Cloned(Commentary)
5	Crystallization (Commentary)
540	Disease/ Diagnostics
1	Expression
15	General Information
3	General Stability
14	Inhibitors
5	kcat/KM [mM/s]
1	Ki Value [mM]
25	KM Value [mM]
16	Localization
16	Metals/Ions
12	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
255	Organism
1	Oxidation Stability
3	Pathway
20	PDB ID
8	pH Optimum
1	pH Range
2	Posttranslational Modification
65	Protein Variants
16	Purification (Commentary)
2	Reaction
1	Reaction Type
73	Reference
1	Renatured (Commentary)
110	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
164	Substrates and Products (Substrate)
11	Subunits
51	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
13	Turnover Number [1/s]

Application

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Application on EC 3.5.1.15 - aspartoacylase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

2 entries

nutrition

Sus scrofa

-

development of a general and simple procedure for the resolution of racemic amino acids

288852

pharmacology

Homo sapiens

P45381

the enzyme is the taget for treatment of Canavan disease, enzyme replacement therapy can potentially be used to overcome these defects if a stable enzyme form that can gain access to the appropriate neural cells can be produced. PEGylated form of aspartoacylase are able to traverse the blood-brain barrier and show dramatic enhancement in brain tissue access and distribution, overview. Examination of the effect of enzyme administration on the immunological response

734698

medicine

Homo sapiens

-

diagnosis of Canavan disease, an autosomal recessive neurodegenerative disorder characterized by aspartoacylase deficiency, technique for prenatal diagnosis

209005, 209006, 209007, 209008

medicine

Homo sapiens

-

mutations in the aspartoacylase aspA gene are implicated as the cause of Canavan Disease

720476