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Literature summary for 3.5.1.15 extracted from
- Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes (1999), J. Mol. Neurosci., 13, 47-53.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | diagnosis of Canavan disease, an autosomal recessive neurodegenerative disorder characterized by aspartoacylase deficiency, technique for prenatal diagnosis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene for the production of aspartoacylase is located on chromosome 17 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-aspartic acid + H2O | Homo sapiens | - |
acetate + aspartic acid | - |
? |  |
| N-acetyl-L-aspartic acid + H2O | Rattus norvegicus | - |
acetate + aspartic acid | - |
? | |
| N-acetyl-L-aspartic acid + H2O | Carassius auratus | - |
acetate + aspartic acid | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Carassius auratus | - |
goldfish | - |
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Carassius auratus | - |
| brain | enzyme activity expressed only in oligodendrocytes | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-aspartic acid + H2O | - |
Homo sapiens | acetate + aspartic acid | - |
? | |
| N-acetyl-L-aspartic acid + H2O | - |
Rattus norvegicus | acetate + aspartic acid | - |
? | |
| N-acetyl-L-aspartic acid + H2O | - |
Carassius auratus | acetate + aspartic acid | - |
? | |
| N-acyl L-aspartic acid + H2O | - |
Homo sapiens | acetate + L-aspartate | - |
? | |
| N-acyl L-aspartic acid + H2O | - |
Rattus norvegicus | acetate + L-aspartate | - |
? | |
| N-acyl L-aspartic acid + H2O | - |
Carassius auratus | acetate + L-aspartate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAA acylase | - |
Rattus norvegicus |
| NAA acylase | - |
Carassius auratus |
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Release 2023.1 (January 2023)
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