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Literature summary for 3.5.1.15 extracted from

  • Francis, J.S.; Olariu, A.; McPhee, S.W.; Leone, P.
    Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis (2006), J. Neurosci. Res., 84, 151-169.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
quantitative expression analysis in brain of wild-type and tremor rats Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetylaspartic acid + H2O Rattus norvegicus the enzyme is involved in negative regulation of brain-derived neurotrophic factor, BDNF, and timing of postnatal oligodendrogenesis, overview L-asparatate + acetate
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9R1T5 female wild-type Kyoto-Wistar and tremor rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain in situ hybridization, quantitative expression analysis in brain of wild-type and tremor rats, overview Rattus norvegicus
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neuron primary cortical neuron culture Rattus norvegicus
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neuron-oligodendrocyte co-culture neurons from wild-type embryos are co-cultured with oligodendrocytes prepared from either wild-type or tremor rats Rattus norvegicus
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oligodendrocyte primary cell culture Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetylaspartic acid + H2O
-
 Rattus norvegicus L-asparatate + acetate
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 ?
N-acetylaspartic acid + H2O the enzyme is involved in negative regulation of brain-derived neurotrophic factor, BDNF, and timing of postnatal oligodendrogenesis, overview Rattus norvegicus L-asparatate + acetate
-
 ?

Synonyms

Synonyms Comment Organism
ASPA
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 Rattus norvegicus