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Literature summary for 3.5.1.15 extracted from

  • George, R.L.; Huang, W.; Naggar, H.A.; Smith, S.B.; Ganapathy, V.
    Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse (2004), Biochim. Biophys. Acta, 1690, 63-69.
    View publication on PubMed
Search for more literature for 3.5.1.15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme functions in concert with the plasma membrane transporter NaDC3, that specifically transports N-acetylaspartic acid into the cell ?
-
 ?
N-acetylaspartic acid + H2O Mus musculus enzyme deficiency, due to mutations of aspartoacylase II, causes the Canavan disease, which is associated with optical neuropathy L-asparatate + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ciliary body
-
 Mus musculus
-
eye ocular tissue, enzyme expression pattern Mus musculus
-
iris
-
 Mus musculus
-
lens
-
 Mus musculus
-
additional information co-localization with plasma membrane transporter NaDC3 in the optic system, in situ hybridization, overview Mus musculus
-
retina
-
 Mus musculus
-
retinal pigment epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme functions in concert with the plasma membrane transporter NaDC3, that specifically transports N-acetylaspartic acid into the cell Mus musculus ?
-
 ?
N-acetylaspartic acid + H2O
-
 Mus musculus L-asparatate + acetate
-
 ?
N-acetylaspartic acid + H2O enzyme deficiency, due to mutations of aspartoacylase II, causes the Canavan disease, which is associated with optical neuropathy Mus musculus L-asparatate + acetate
-
 ?

Synonyms

Synonyms Comment Organism
aspartoacylase II
-
 Mus musculus