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Literature summary for 3.5.1.15 extracted from

  • Francis, J.S.; Strande, L.; Markov, V.; Leone, P.
    Aspartoacylase supports oxidative energy metabolism during myelination (2012), J. Cereb. Blood Flow Metab., 32, 1725-1736.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.15

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
oligodendrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-aspartate + H2O
-
 Mus musculus L-aspartate + acetate
-
 ?

Synonyms

Synonyms Comment Organism
ASPA
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is decreased during the early stages of postnatal development down

General Information

General Information Comment Organism
physiological function aspartoacylase activity supports adenosine triphosphate synthesis in oligodendrocytes during hypoglycemia in vitro. The loss of enzyme function during the early stages of postnatal development significantly compromises oligodendrocyte oxidative integrity Mus musculus