3.4.24.24: gelatinase A

This is an abbreviated version!
For detailed information about gelatinase A, go to the full flat file.

Word Map on EC 3.4.24.24

3.4.24.24

mmp-9

metalloproteinases

zymography

metastasis

timp-2

endothelial

angiogenesis

artery

fibrosis

necrosis

gelatinolytic

invasiveness

transwell

basement

tnf

mt1-mmp

plasminogen

cardiac

neutrophil

aortic

vessel

integrins

fibronectin

upa

melanoma

laminin

matrigel

vimentin

myocardial

interstitial

proteinases

lymph

ventricular

e-cadherin

nude

angiogenic

aneurysm

mesenchymal

stromelysins

anti-metastatic

fak

medicine

elastin

cox-2

synthesis

urokinase

collagenases

urokinase-type

collagenolytic

tgf-beta1

diagnostics

lipocalin

boyden

Reaction

Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-/-Ile-Ala-Gly-Gln =

Synonyms

72 kDa Gelatinase, 72 kDa Gelatinase type A, 72 kDa type IV collagenase, 72-kDa Gelatinase, Collagenase IV, Collagenase type IV, GelA, gelatinase, gelatinase A, human gelatinase A, human matrix metalloproteinase 2, human matrix metalloproteinase-2, LvMMP-2, matrix metallopeptidase 2, matrix metalloprotease 2, Matrix metalloproteinase 2, matrix metalloproteinase-2, matrix metalloprotenase-2, metalloproteinase-2, metrix metalloproteinase-2, MMP 2, MMP-2, MMP2, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.24 gelatinase A

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Results	in table
22	Activating Compound
1135	AA Sequence
13	Application
1	CAS Registry Number
31	Cloned(Commentary)
5	Crystallization (Commentary)
37154	Disease/ Diagnostics
10	Expression
33	General Information
2	General Stability
39	IC50 Value
184	Inhibitors
1	kcat/KM [mM/s]
7	Ki Value [mM]
48	KM Value [mM]
41	Localization
59	Metals/Ions
42	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
280	Organism
15	PDB ID
29	pH Optimum
7	pH Range
3	pI Value
15	Posttranslational Modification
46	Protein Variants
28	Purification (Commentary)
1	Reaction
1	Reaction Type
114	Reference
4	Renatured (Commentary)
161	Source Tissue
10	Specific Activity [micromol/min/mg]
200	Substrates and Products (Substrate)
30	Subunits
166	Synonyms
26	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
46	Turnover Number [1/s]

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16.7 - 19.5

Ac-Pro-Leu-Gly-[2-mercapto-4-methylpentanoyl]-Leu-Gly-OEt

2 entries

1.6

Acetyl-Pro-Leu-Gly-thioester-Leu-Leu-Gly ethyl ester