3.4.24.24: gelatinase A

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For detailed information about gelatinase A, go to the full flat file.

Reaction

Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-/-Ile-Ala-Gly-Gln =

Synonyms

72 kDa Gelatinase, 72 kDa Gelatinase type A, 72 kDa type IV collagenase, 72-kDa Gelatinase, Collagenase IV, Collagenase type IV, GelA, gelatinase, gelatinase A, human gelatinase A, human matrix metalloproteinase 2, human matrix metalloproteinase-2, LvMMP-2, matrix metallopeptidase 2, matrix metalloprotease 2, Matrix metalloproteinase 2, matrix metalloproteinase-2, matrix metalloprotenase-2, metalloproteinase-2, metrix metalloproteinase-2, MMP 2, MMP-2, MMP2, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.24 gelatinase A

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Results	in table
22	Activating Compound
1135	AA Sequence
13	Application
1	CAS Registry Number
31	Cloned(Commentary)
5	Crystallization (Commentary)
37154	Disease/ Diagnostics
10	Expression
33	General Information
2	General Stability
39	IC50 Value
184	Inhibitors
1	kcat/KM [mM/s]
7	Ki Value [mM]
48	KM Value [mM]
41	Localization
59	Metals/Ions
42	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
280	Organism
15	PDB ID
29	pH Optimum
7	pH Range
3	pI Value
15	Posttranslational Modification
46	Protein Variants
28	Purification (Commentary)
1	Reaction
1	Reaction Type
114	Reference
4	Renatured (Commentary)
161	Source Tissue
10	Specific Activity [micromol/min/mg]
200	Substrates and Products (Substrate)
30	Subunits
166	Synonyms
26	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
46	Turnover Number [1/s]

General Stability

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General Stability on EC 3.4.24.24 - gelatinase A

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

stable in aqueous solution

Bos taurus

-

670231

the plasmatic half-life of human recombinant pro-MMP-2, assessed after the intravenous injection of 500 ng of the proenzyme in MMP-2-deficient mice is 19 min

Homo sapiens

-

712613