3.4.24.24: gelatinase A
This is an abbreviated version!
For detailed information about gelatinase A, go to the full flat file.
Word Map on EC 3.4.24.24
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3.4.24.24
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mmp-9
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metalloproteinases
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zymography
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metastasis
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timp-2
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endothelial
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angiogenesis
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artery
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fibrosis
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necrosis
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gelatinolytic
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invasiveness
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transwell
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basement
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tnf
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mt1-mmp
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plasminogen
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cardiac
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neutrophil
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aortic
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vessel
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integrins
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fibronectin
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upa
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melanoma
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laminin
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matrigel
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vimentin
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myocardial
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interstitial
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proteinases
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lymph
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ventricular
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e-cadherin
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nude
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angiogenic
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aneurysm
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mesenchymal
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stromelysins
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anti-metastatic
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fak
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medicine
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elastin
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cox-2
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synthesis
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urokinase
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collagenases
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urokinase-type
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collagenolytic
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tgf-beta1
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diagnostics
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lipocalin
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boyden
- 3.4.24.24
- mmp-9
- metalloproteinases
-
zymography
- metastasis
- timp-2
- endothelial
- angiogenesis
- artery
- fibrosis
- necrosis
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gelatinolytic
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invasiveness
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transwell
-
basement
- tnf
- mt1-mmp
- plasminogen
- cardiac
- neutrophil
- aortic
- vessel
- integrins
- fibronectin
- upa
- melanoma
- laminin
- matrigel
- vimentin
- myocardial
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interstitial
- proteinases
- lymph
- ventricular
- e-cadherin
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nude
-
angiogenic
- aneurysm
- mesenchymal
- stromelysins
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anti-metastatic
- fak
- medicine
- elastin
- cox-2
- synthesis
- urokinase
- collagenases
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urokinase-type
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collagenolytic
- tgf-beta1
- diagnostics
-
lipocalin
-
boyden
Reaction
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-/-Ile-Ala-Gly-Gln =
Synonyms
72 kDa Gelatinase, 72 kDa Gelatinase type A, 72 kDa type IV collagenase, 72-kDa Gelatinase, Collagenase IV, Collagenase type IV, GelA, gelatinase, gelatinase A, human gelatinase A, human matrix metalloproteinase 2, human matrix metalloproteinase-2, LvMMP-2, matrix metallopeptidase 2, matrix metalloprotease 2, Matrix metalloproteinase 2, matrix metalloproteinase-2, matrix metalloprotenase-2, metalloproteinase-2, metrix metalloproteinase-2, MMP 2, MMP-2, MMP2, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase
ECTree
3.4.24.24 gelatinase AAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.24.24 - gelatinase A
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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aged arterial wall, colocalization of activated enzyme and transforming growth factor TGF-beta1. Treatment of young aortic rings with activated enzyme enhances active transforming growth factor TGF-beta-1, collagen, and fibronectin expression to the level of untreated old counterparts
the enzyme is overexpressed in tumors, it is expressed in all tumors tested
higher intensity of staining of MMP-2 is observed in regions of invasion of the muscularis mucosa compared with superficial portions of the tumor in colorectal cancer
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demineralized dentin matrix, extraction is best at acidic conditions of pH 2-3 compared to pH 7.4-EDTA-containing extracts
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derived from premenopausal women aged 45-55 years who underwent total abdominal hysterectomy
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regional lymph node invasion and distant metastases are more frequently observed in the MMP-2 positive cases, the MMP-2/TIMP-2 ratio is also positively correlated with MMP-2 activity, overview
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plasma prepared from blood emerging from a skin wound inflicted for the measurement of the bleeding time, shed blood, and simultaneously from venous blood in 27 healthy human volunteers, with and without treatment of the individuals with acetylsalicylic acid before. MMP-2 activity is higher in shed blood. Acetylsalicylic acid has no effect on MMP-2 secretion, overview
Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host. Analysis of the patterns of matrix metalloproteinase 9 (MMP-9) and 2 (MMP-2) isoforms in sputum samples, overview
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GelA is expressed in fibroblasts surrounding apoptotic cells, spatial localization of MT1-MMP and GelA mRNAs in the tail during natural metamorphosis, overview
additional information
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human platelets contain matrix metalloproteinase 2 and release it upon activation
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expression analysis in brain after implantation of 9L glioma cells, overview
recombinant pro-enzyme and recombinant mature, activated enzyme
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from HeLa cells co-infected with each of the recombinant Vaccinia viruses and with vTF7-3
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GelA is expressed in fibroblasts surrounding apoptotic cells of intestine and tail
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GelA is expressed in fibroblasts surrounding apoptotic cells, expression of GelA is downregulated in the intestine by the end of metamorphosis when the tail is completely resorbed, and the adult intestine has formed
infundibulum, magnum, isthmus, and shell gland. Developmental changes, overview
Gallus gallus Hy-Line Brown
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infundibulum, magnum, isthmus, and shell gland. Developmental changes, overview
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distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers, quantification of MMP2 in muscle, overview
distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers, quantification of MMP2 in muscle, overview. On average, about 57% of the MMP2, along with most of the GAPDH, in the skinned fibers is freely diffusible in the cytosol, about 6% of the MMP2 dissociates with the subsequent 10-min Triton X-100 treatment, and about 37% of the MMP2 remains in the skinned fiber
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vascular smooth muscle, colocalization of activated enzyme and transforming growth factor TGF-beta1. Treatment of vascular smooth muscle cells in vitro with activated enzyme enhances active transforming growth factor TGF-beta-1, collagen, and fibronectin expression to the level of untreated old counterparts
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activity of MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure, overview
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activity of MMP-2 in odontogenic region of the rat incisor tooth after post shortening procedure, overview
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enzyme level and expression analysis in response to advanced glycation products
additional information
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expression analysis of MMP-2 in dog tumor tissues, overview
additional information
quantitative enzyme tissue expression analysis in the chicken oviduct during maturation
additional information
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quantitative enzyme tissue expression analysis in the chicken oviduct during maturation
additional information
Gallus gallus Hy-Line Brown
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quantitative enzyme tissue expression analysis in the chicken oviduct during maturation
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additional information
quantitative real time PCR enzyme expression analysis and immunohistochemic analysis in glioblastoma
additional information
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quantitative real time PCR enzyme expression analysis and immunohistochemic analysis in glioblastoma
additional information
circulating hMMP2is significantly increased in diabetic patients compared to controls and significantly correlated with the serum C-peptide levels
additional information
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circulating hMMP2is significantly increased in diabetic patients compared to controls and significantly correlated with the serum C-peptide levels
additional information
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MMP-2 immunoexpression in all phases of estrous cycle
additional information
the enzyme is highly expressed in epidermis, located to endoplasmic reticulum in S2 cells
additional information
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the enzyme is highly expressed in epidermis, located to endoplasmic reticulum in S2 cells
additional information
in rat soleus muscle and other tissues, pro- and active MMP2 show gelatinase activity, as well as a higher band that has been reported previously to represent a rodent-specific glycosylated MMP2
additional information
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MMP-2 activity in tissues taken from newborn piglets undergoing hypoxia and reoxygenation, overview
additional information
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co-localization of MT1-MMP and GelA mRNAs during amphibian development, overview
