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3.4.24.24: gelatinase A

This is an abbreviated version!
For detailed information about gelatinase A, go to the full flat file.

Word Map on EC 3.4.24.24

Reaction

Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-/-Ile-Ala-Gly-Gln =

Synonyms

72 kDa Gelatinase, 72 kDa Gelatinase type A, 72 kDa type IV collagenase, 72-kDa Gelatinase, Collagenase IV, Collagenase type IV, GelA, gelatinase, gelatinase A, human gelatinase A, human matrix metalloproteinase 2, human matrix metalloproteinase-2, LvMMP-2, matrix metallopeptidase 2, matrix metalloprotease 2, Matrix metalloproteinase 2, matrix metalloproteinase-2, matrix metalloprotenase-2, metalloproteinase-2, metrix metalloproteinase-2, MMP 2, MMP-2, MMP2, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.24 gelatinase A

Expression

Expression on EC 3.4.24.24 - gelatinase A

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression and activity of MMP-2 is 6fold induced by osteopontin through binding to integrin avb3 and CD44v6 in hepatocellular carcinoma cells SMMC7721 and HepG2
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in vitro, both angiotensin II (ANGII) and ANGI stimulation significantly increase expression of MMP2
inhibition of the SDF-1a/CXCR4 axis downregulates the rhOPN-induced MMP-2 expression and activity
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matrix metalloproteinase 2 activity decreases in human periodontal ligament fibroblast cultures submitted to simulated orthodontic force by centrifugation (141xg) for 30, 60, 90, and 120 min at 24 h regardless of the duration of centrifugation and at 48 h in cells centrifuged for 30 min only
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Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host
oxidative stress increases the expression of LvMMP-2
peptide Ile-Trp isoleucine-tryptophan inhibits expression and activity of matrix metalloproteinase-2 in rat aorta, mechanism of action, overview. The inhibitor significantly inhibits ANGI, but not ANGII mediated increase in expression of MMP2, while losartan also blocks effects of ANGII. Signaling pathways regulating MMP2 expression in endothelial cells and smooth muscle cells are similarly inhibited after treatment with Ile-Trp or captopril. Ile-Trp not only inhibits the MMP2 expression, but also its activation assessed with gelatin zymography
profibrogenic gene expression of MMP-2 is down-regulated (75% decrement) in response to adenoviral delivery of dominant-negative transforming growth factor beta type II receptor in hepatic stellate cells
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promoter activity of LvMMP-2 is enhanced by LvNRF2 in a ARE site dependent-manner. Overexpression of Lvc-Jun in S2 cells demonstrates that AP-1 is also involved in LvMMP-2 regulation
significant progressive increase in total MMP-2 plasma levels with progression from adenomatous polyps through advancing Dukes stages