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3.4.23.B19: plasmepsin V

This is an abbreviated version!
For detailed information about plasmepsin V, go to the full flat file.

Word Map on EC 3.4.23.B19

Reaction

cleavage of hemoglobin. In contrast to the food vacuole plasmepsins, detergent-solubilized PM V does not bind the aspartic protease inhibitor pepstatin. =

Synonyms

plasmepsin V, Plm V, PlmV, PM V, PMV, PMVm84, PMVp37

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B19 plasmepsin V

Reference

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Reference on EC 3.4.23.B19 - plasmepsin V

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Klemba, M.; Goldberg, D.E.
Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum.
Mol. Biochem. Parasitol.
143
183-191
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Russo, I.; Babbitt, S.; Muralidharan, V.; Butler, T.; Oksman, A.; Goldberg, D.E.
Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
Nature
463
632-636
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Boddey, J.A.; Hodder, A.N.; Guenther, S.; Gilson, P.R.; Patsiouras, H.; Kapp, E.A.; Pearce, J.A.; de Koning-Ward, T.F.; Simpson, R.J.; Crabb, B.S.; Cowman, A.F.
An aspartyl protease directs malaria effector proteins to the host cell
Nature
463
627-631
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Sittikul, P.; Songtawee, N.; Kongkathip, N.; Boonyalai, N.
In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V
Biochimie
152
159-173
2018
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Gazdik, M.; Jarman, K.E.; ONeill, M.T.; Hodder, A.N.; Lowes, K.N.; Jousset Sabroux, H.; Cowman, A.F.; Boddey, J.A.; Sleebs, B.E.
Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V
Bioorg. Med. Chem.
24
1993-2010
2016
Plasmodium falciparum (Q8I6Z5)
Manually annotated by BRENDA team
Meissner, K.A.; Kronenberger, T.; Maltarollo, V.G.; Trossini, G.H.G.; Wrenger, C.
Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening
Chem. Biol. Drug Des.
93
300-312
2019
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Boonyalai, N.; Sittikul, P.; Yuvaniyama, J.
Plasmodium falciparum plasmepsin V (PfPMV) Insights into recombinant expression, substrate specificity and active site structure
Mol. Biochem. Parasitol.
201
5-15
2015
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Sappakhaw, K.; Takasila, R.; Sittikul, P.; Wattana-Amorn, P.; Assavalapsakul, W.; Boonyalai, N.
Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates Substrate specificity and enzyme inhibition
Mol. Biochem. Parasitol.
204
51-63
2015
Plasmodium vivax (A0A0H4FQ60), Plasmodium vivax, Plasmodium vivax Thai (A0A0H4FQ60)
Manually annotated by BRENDA team
Loymunkong, C.; Sittikul, P.; Songtawee, N.; Wongpanya, R.; Boonyalai, N.
Yield improvement and enzymatic dissection of Plasmodium falciparum plasmepsin V
Mol. Biochem. Parasitol.
231
111188
2019
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
L, M.; Soliman, M.E.
The binding landscape of plasmepsin V and the implications for flap dynamics
Mol. Biosyst.
12
1457-1467
2016
Plasmodium vivax
Manually annotated by BRENDA team
Marapana, D.S.; Dagley, L.F.; Sandow, J.J.; Nebl, T.; Triglia, T.; Pasternak, M.; Dickerman, B.K.; Crabb, B.S.; Gilson, P.R.; Webb, A.I.; Boddey, J.A.; Cowman, A.F.
Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte
Nat. Microbiol.
3
1010-1022
2018
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Hodder, A.N.; Sleebs, B.E.; Czabotar, P.E.; Gazdik, M.; Xu, Y.; ONeill, M.T.; Lopaticki, S.; Nebl, T.; Triglia, T.; Smith, B.J.; Lowes, K.; Boddey, J.A.; Cowman, A.F.
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes
Nat. Struct. Mol. Biol.
22
590-596
2015
Plasmodium vivax (Q6PRR9), Plasmodium vivax, Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Tarr, S.J.; Osborne, A.R.
Experimental determination of the membrane topology of the Plasmodium protease plasmepsin V
PLoS ONE
10
e0121786
2015
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Boonyalai, N.; Collins, C.R.; Hackett, F.; Withers-Martinez, C.; Blackman, M.J.
Essentiality of Plasmodium falciparum plasmepsin V
PLoS ONE
13
e0207621
2018
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
McGillewie, L.; Soliman, M.E.
Flap flexibility amongst plasmepsins I, II, III, IV, and V Sequence, structural, and molecular dynamics analyses
Proteins
83
1693-1705
2015
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team
Bedi, R.K.; Patel, C.; Mishra, V.; Xiao, H.; Yada, R.Y.; Bhaumik, P.
Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
Sci. Rep.
6
31420
2016
Plasmodium falciparum (Q8I6Z5), Plasmodium falciparum
Manually annotated by BRENDA team